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2020

Acyl-ghrelin is permissive for the normal counterregulatory response to insulin-induced hypoglycemia

Shankar, K., Gupta, D., Mani, B. K., Findley, B. G., Lord, C. C., Osborne-Lawrence, S., Metzger, N. P., Pietra, C., Liu, C., Berglund, E. D. & Zigman, J. M., Feb 1 2020, In : Diabetes. 69, 2, p. 228-237 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

ADP-ribosylation levels and patterns correlate with gene expression and clinical outcomes in ovarian cancers

Conrad, L. B., Lin, K. Y., Nandu, T., Gibson, B. A., Lea, J. S. & Lee Kraus, W., Jan 1 2020, In : Molecular Cancer Therapeutics. 19, 1, p. 282-291 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

Swift, R. P., Rajaram, K., Liu, H. B., Dziedzic, A., Jedlicka, A. E., Roberts, A. D., Matthews, K. A., Jhun, H., Bumpus, N. N., Tewari, S. G., Wallqvist, A. & Prigge, S. T., 2020, In : PLoS pathogens. 16, 2, e1008316.

Research output: Contribution to journalArticle

Open Access

Analysis of asymmetry in lipid and content mixing assays with reconstituted proteoliposomes containing the neuronal SNAREs

Pan, Y. Z., Liu, X. & Rizo, J., Dec 1 2020, In : Scientific reports. 10, 1, 2907.

Research output: Contribution to journalArticle

Open Access

Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis

Back, P. S., O'Shaughnessy, W. J., Moon, A. S., Dewangan, P. S., Hu, X., Sha, J., Wohlschlegel, J. A., Bradley, P. J. & Reese, M. L., Jun 2 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 22

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis

Hight, S. K., Mootz, A., Kollipara, R. K., McMillan, E., Yenerall, P., Otaki, Y., Li, L. S., Avila, K., Peyton, M., Rodriguez-Canales, J., Mino, B., Villalobos, P., Girard, L., Dospoy, P., Larsen, J., White, M. A., Heymach, J. V., Wistuba, I. I., Kittler, R. & Minna, J. D., Aug 2020, In : Neoplasia (United States). 22, 8, p. 294-310 17 p.

Research output: Contribution to journalArticle

Open Access

A novel functional cross-interaction between opioid and pheromone signaling may be involved in stress avoidance in Caenorhabditis elegans

Park, J. Y., Cheong, M. C., Cho, J. Y., Koo, H. S. & Paik, Y. K., Dec 1 2020, In : Scientific reports. 10, 1, 7524.

Research output: Contribution to journalArticle

Open Access

A Proteomic Connectivity Map for Characterizing the Tumor Adaptive Response to Small Molecule Chemical Perturbagens

Zi, Z., Zhang, Y., Zhang, P., Ding, Q., Chu, M., Chen, Y., Minna, J. D. & Yu, Y., Jan 17 2020, In : ACS chemical biology. 15, 1, p. 140-150 11 p.

Research output: Contribution to journalArticle

ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models

Vue, T. Y., Kollipara, R. K., Borromeo, M. D., Smith, T., Mashimo, T., Burns, D. K., Bachoo, R. & Johnson, J. E., 2020, (Accepted/In press) In : GLIA.

Research output: Contribution to journalArticle

Open Access

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells

Lotsberg, M. L., Wnuk-Lipinska, K., Terry, S., Tan, T. Z., Lu, N., Trachsel-Moncho, L., Røsland, G. V., Siraji, M. I., Hellesøy, M., Rayford, A., Jacobsen, K., Ditzel, H. J., Vintermyr, O. K., Bivona, T. G., Minna, J., Brekken, R. A., Baguley, B., Micklem, D., Akslen, L. A., Gausdal, G. & 5 others, Simonsen, A., Thiery, J. P., Chouaib, S., Lorens, J. B. & Engelsen, A. S. T., Jun 2020, In : Journal of Thoracic Oncology. 15, 6, p. 973-999 27 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus

Cho, Y. S., Li, S., Wang, X., Zhu, J., Zhuo, S., Han, Y., Yue, T., Yang, Y. & Jiang, J., Jan 1 2020, In : Genes & development. 34, 1-2, p. 53-71 19 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Characterization of basal and estrogen-regulated antisense transcription in breast cancer cells: Role in regulating sense transcription

Hou, T. Y., Nandu, T., Li, R., Chae, M., Murakami, S. & Kraus, W. L., Apr 15 2020, In : Molecular and Cellular Endocrinology. 506, 110746.

Research output: Contribution to journalArticle

Cryo-EM structure of the human cohesin-NIPBL-DNA complex

Shi, Z., Gao, H., Bai, X. C. & Yu, H., Jun 26 2020, In : Science (New York, N.Y.). 368, 6498, p. 1454-1459 6 p.

Research output: Contribution to journalArticle

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

Kuo, Y. C., Chen, H., Shang, G., Uchikawa, E., Tian, H., Bai, X. C. & Zhang, X., Dec 1 2020, In : Nature communications. 11, 1, 1953.

Research output: Contribution to journalArticle

Open Access

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation

Ayoade, K. O., Carranza, F. R., Cho, W. H., Wang, Z., Kliewer, S. A., Mangelsdorf, D. J. & Stoltzfus, J. D. C., Apr 1 2020, In : Parasites and Vectors. 13, 1, 162.

Research output: Contribution to journalArticle

Open Access

DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi

Marivin, A., Maziarz, M., Zhao, J., DiGiacomo, V., Calvo, I. O., Mann, E. A., Ear, J., Blanco-Canosa, J. B., Ross, E. M., Ghosh, P. & Garcia-Marcos, M., Feb 21 2020, In : Journal of Biological Chemistry. 295, 8, p. 2270-2284 15 p.

Research output: Contribution to journalArticle

Detection of lymph node metastases by ultra-pH-sensitive polymeric nanoparticles

Bennett, Z. T., Feng, Q., Bishop, J. A., Huang, G., Sumer, B. D. & Gao, J., 2020, In : Theranostics. 10, 7, p. 3340-3350 11 p.

Research output: Contribution to journalArticle

Open Access

Differential regulation of breast cancer bone metastasis by PARP1 and PARP2

Zuo, H., Yang, D., Yang, Q., Tang, H., Fu, Y. X. & Wan, Y., Dec 1 2020, In : Nature communications. 11, 1, 1578.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases

Matthews, K. A., Senagbe, K. M., Nötzel, C., Gonzales, C. A., Tong, X., Rijo-Ferreira, F., Bhanu, N. V., Miguel-Blanco, C., Lafuente-Monasterio, M. J., Garcia, B. A., Kafsack, B. F. C. & Martinez, E. D., May 8 2020, In : ACS infectious diseases. 6, 5, p. 1058-1075 18 p.

Research output: Contribution to journalArticle

Electrophysiological Properties of Genetically Identified Histaminergic Neurons

Michael, N. J., Zigman, J. M., Williams, K. W. & Elmquist, J. K., 2020, (Accepted/In press) In : Neuroscience.

Research output: Contribution to journalArticle

Open Access

Expression of large tumour suppressor (LATS) kinases modulates chemotherapy response in advanced non-small cell lung cancer

Luo, S. Y., Kwok, H. H., Yang, P. C., Ip, M. S. M., Minna, J. D. & Lam, D. C. L., Apr 1 2020, In : Translational Lung Cancer Research. 9, 2, p. 294-305 12 p.

Research output: Contribution to journalArticle

Open Access

FRA1 contributes to MEK-ERK pathway-dependent PD-L1 upregulation by KRAS mutation in premalignant human bronchial epithelial cells

Lee, M. H., Yanagawa, J., Tran, L., Walser, T. C., Bisht, B., Fung, E., Park, S. J., Zeng, G., Krysan, K., Wallace, W. D., Paul, M. K., Girard, L., Gao, B., Minna, J. D., Dubinett, S. M. & Lee, J. M., Jan 1 2020, In : American Journal of Translational Research. 12, 2, p. 409-427 19 p.

Research output: Contribution to journalArticle

1 Scopus citations

From clinical specimens to human cancer preclinical models—a journey the NCI-cell line database—25 years later

Mulshine, J. L., Ujhazy, P., Antman, M., Burgess, C. M., Kuzmin, I., Bunn, P. A., Johnson, B. E., Roth, J. A., Pass, H. I., Ross, S. M., Aldige, C. R., Wistuba, I. I. & Minna, J. D., Aug 1 2020, In : Journal of Cellular Biochemistry. 121, 8-9, p. 3986-3999 14 p.

Research output: Contribution to journalArticle

Open Access

GCNA Preserves Genome Integrity and Fertility Across Species

Bhargava, V., Goldstein, C. D., Russell, L., Xu, L., Ahmed, M., Li, W., Casey, A., Servage, K., Kollipara, R., Picciarelli, Z., Kittler, R., Yatsenko, A., Carmell, M., Orth, K., Amatruda, J. F., Yanowitz, J. L. & Buszczak, M., Jan 6 2020, In : Developmental cell. 52, 1, p. 38-52.e10

Research output: Contribution to journalArticle

3 Scopus citations

Genome-wide analysis and functional prediction of the estrogen-regulated transcriptional response in the mouse uterus

Vasquez, Y. M., Nandu, T. S., Kelleher, A. M., Ramos, E. I., Gadad, S. S. & Kraus, W. L., Feb 14 2020, In : Biology of reproduction. 102, 2, p. 327-338 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut

Li, S., Tian, A., Li, S., Han, Y., Wang, B. & Jiang, J., Apr 6 2020, In : The Journal of cell biology. 219, 4

Research output: Contribution to journalArticle

Open Access

HIF2-induced long noncoding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis

Niu, Y., Bao, L., Chen, Y., Wang, C., Luo, M., Zhang, B., Zhou, M., Wang, J. E., Fang, Y. V., Kumar, A., Xing, C., Wang, Y. & Luo, W., Mar 1 2020, In : Cancer research. 80, 5, p. 964-975 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Inhibiting the GAS6/AXL axis suppresses tumor progression by blocking the interaction between cancer-associated fibroblasts and cancer cells in gastric carcinoma

Bae, C. A., Ham, I. H., Oh, H. J., Lee, D., Woo, J., Son, S. Y., Yoon, J. H., Lorens, J. B., Brekken, R. A., Kim, T. M., Han, S. U., Park, W. S. & Hur, H., 2020, (Accepted/In press) In : Gastric Cancer.

Research output: Contribution to journalArticle

1 Scopus citations

Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail

Lu, L., Chen, Z., Lin, X., Tian, L., Su, Q., An, P., Li, W., Wu, Y., Du, J., Shan, H., Chiang, C. M. & Wang, H., Jan 1 2020, In : Cell Death and Differentiation. 27, 1, p. 255-268 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs

Bacon, C. W., Challa, A., Hyder, U., Shukla, A., Borkar, A. N., Bayo, J., Liu, J., Wu, S. Y., Chiang, C. M., Kutateladze, T. G. & D'Orso, I., Jun 18 2020, In : Molecular cell. 78, 6, p. 1133-1151.e14

Research output: Contribution to journalArticle

1 Scopus citations

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

Li, Q., Sun, Y., Jarugumilli, G. K., Liu, S., Dang, K., Cotton, J. L., Xiol, J., Chan, P. Y., DeRan, M., Ma, L., Li, R., Zhu, L. J., Li, J. H., Leiter, A. B., Ip, Y. T., Camargo, F. D., Luo, X., Johnson, R. L., Wu, X. & Mao, J., May 7 2020, In : Cell Stem Cell. 26, 5, p. 675-692.e8

Research output: Contribution to journalArticle

1 Scopus citations

Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of malaria

Kokkonda, S., Deng, X., White, K. L., El Mazouni, F., White, J., Shackleford, D. M., Katneni, K., Chiu, F. C. K., Barker, H., Mclaren, J., Crighton, E., Chen, G., Angulo-Barturen, I., Jimenez-Diaz, M. B., Ferrer, S., Huertas-Valentin, L., Martinez-Martinez, M. S., Lafuente-Monasterio, M. J., Chittimalla, R., Shahi, S. P. & 9 others, Wittlin, S., Waterson, D., Burrows, J. N., Matthews, D., Tomchick, D., Rathod, P. K., Palmer, M. J., Charman, S. A. & Phillips, M. A., May 14 2020, In : Journal of Medicinal Chemistry. 63, 9, p. 4929-4956 28 p.

Research output: Contribution to journalArticle

Leptin: Less is more

Zhao, S., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., May 1 2020, In : Diabetes. 69, 5, p. 823-829 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Loss of a conserved MAPK causes catastrophic failure in assembly of a specialized cilium-like structure in Toxoplasma gondii

O'Shaughnessy, W. J., Hu, X., Beraki, T., McDougal, M. & Reese, M. L., Apr 15 2020, In : Molecular biology of the cell. 31, 9, p. 881-888 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes

Falck, J., Bruns, C., Hoffmann-Conaway, S., Straub, I., Plautz, E. J., Orlando, M., Munawar, H., Rivalan, M., Winter, Y., Izsvák, Z., Schmitz, D., Hamra, F. K., Hallermann, S., Garner, C. C. & Ackermann, F., Apr 1 2020, In : Journal of Neuroscience. 40, 14, p. 2943-2959 17 p.

Research output: Contribution to journalArticle

Mechanical regulation of glycolysis via cytoskeleton architecture

Park, J. S., Burckhardt, C. J., Lazcano, R., Solis, L. M., Isogai, T., Li, L., Chen, C. S., Gao, B., Minna, J. D., Bachoo, R., DeBerardinis, R. J. & Danuser, G., Feb 27 2020, In : Nature. 578, 7796, p. 621-626 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors

Michael, N. J., Caron, A., Lee, C. E., Castorena, C. M., Lee, S., Zigman, J. M., Williams, K. W. & Elmquist, J. K., May 2020, In : Molecular Metabolism. 35, 100956.

Research output: Contribution to journalArticle

Open Access

Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer

Wang, S., Gilbreath, C., Kollipara, R. K., Sonavane, R., Huo, X., Yenerall, P., Das, A., Ma, S., Raj, G. V. & Kittler, R., Sep 28 2020, In : Cancer Letters. 488, p. 40-49 10 p.

Research output: Contribution to journalArticle

Multiple channels of DEET repellency in Drosophila

Guo, H., Kunwar, K. & Smith, D., Mar 1 2020, In : Pest Management Science. 76, 3, p. 880-887 8 p.

Research output: Contribution to journalArticle

N6-methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming

Chen, Z., Wu, L., Zhou, J., Lin, X., Peng, Y., Ge, L., Chiang, C. M., Huang, H., Wang, H. & He, W., 2020, In : Theranostics. 10, 8, p. 3382-3396 15 p.

Research output: Contribution to journalArticle

Open Access

Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development

Weaver, B. P., Weaver, Y. M., Omi, S., Yuan, W., Ewbank, J. J. & Han, M., May 4 2020, In : Developmental cell. 53, 3, p. 358-369.e6

Research output: Contribution to journalArticle

1 Scopus citations

Opposing Functions of BRD4 Isoforms in Breast Cancer

Wu, S. Y., Lee, C. F., Lai, H. T., Yu, C. T., Lee, J. E., Zuo, H., Tsai, S. Y., Tsai, M. J., Ge, K., Wan, Y. & Chiang, C. M., Jun 18 2020, In : Molecular cell. 78, 6, p. 1114-1132.e10

Research output: Contribution to journalArticle

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

Hernandez, G., Luo, T., Javed, T. A., Wen, L., Kalwat, M. A., Vale, K., Ammouri, F., Husain, S. Z., Kliewer, S. A. & Mangelsdorf, D. J., Jan 8 2020, In : Science translational medicine. 12, 525, eaay5186.

Research output: Contribution to journalArticle

3 Scopus citations

Partial leptin deficiency confers resistance to diet-induced obesity in mice

Zhao, S., Li, N., Zhu, Y., Straub, L., Zhang, Z., Wang, M. Y., Zhu, Q., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., Jul 2020, In : Molecular Metabolism. 37, 100995.

Research output: Contribution to journalArticle

Open Access

PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition

Wang, L. T., Liu, K. Y., Jeng, W. Y., Chiang, C. M., Chai, C. Y., Chiou, S. S., Huang, M. S., Yokoyama, K. K., Wang, S. N., Huang, S. K. & Hsu, S. H., Feb 5 2020, In : EMBO Reports. 21, 2, e48795.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

PCRM1exportome: Database of predicted CRM1-dependent Nuclear Export Signal (NES) motifs in cancer-related genes

Lee, Y., Baumhardt, J. M., Pei, J., Chook, Y. M. & Grishin, N. V., Feb 1 2020, In : Bioinformatics. 36, 3, p. 961-963 3 p.

Research output: Contribution to journalArticle

PET imaging of occult tumours by temporal integration of tumour-acidosis signals from pH-sensitive 64Cu-labelled polymers

Huang, G., Zhao, T., Wang, C., Nham, K., Xiong, Y., Gao, X., Wang, Y., Hao, G., Ge, W. P., Sun, X., Sumer, B. D. & Gao, J., Mar 1 2020, In : Nature Biomedical Engineering. 4, 3, p. 314-324 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons

Mona, B., Villarreal, J., Savage, T. K., Kollipara, R. K., Boisvert, B. E. & Johnson, J. E., May 1 2020, In : Genes and Development. 34, 9-10, p. 621-636 16 p.

Research output: Contribution to journalArticle

Open Access

Progress towards drug discovery for Friedreich's Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein

Shen, X., Wong, J., Prakash, T. P., Rigo, F., Li, Y., Napierala, M. & Corey, D. R., Jun 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 11, 115472.

Research output: Contribution to journalArticle