The Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research

Research Output 1967 2019

Filter
Article
2019

AIF: an acquired metabolic liability in lung cancer

Faubert, B., DeBerardinis, R. J. & Minna, J. D., Jan 1 2019, In : Cell Research.

Research output: Contribution to journalArticle

Open Access
Lung Neoplasms

ClickGene: An open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration

Bi, J. H., Tong, Y. F., Qiu, Z. W., Yang, X. F., Minna, J., Gazdar, A. F. & Song, K., Jun 26 2019, In : BioData Mining. 12, 1, 12.

Research output: Contribution to journalArticle

Open Access
Genome-Wide Association Study
Cancer
Genome
Visualization
Genes

Development and Validation of a Pathology Image Analysis-based Predictive Model for Lung Adenocarcinoma Prognosis - A Multi-cohort Study

Luo, X., Yin, S., Yang, L., Fujimoto, J., Yang, Y., Moran, C., Kalhor, N., Weissferdt, A., Xie, Y., Gazdar, A. F., Minna, J. D., Wistuba, I. I., Mao, Y. & Xiao, G., Dec 1 2019, In : Scientific Reports. 9, 1, 6886.

Research output: Contribution to journalArticle

Open Access
Cohort Studies
Pathology
Adenocarcinoma
Lung
Neoplasms

Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis

Bansal, M., He, J., Peyton, M., Kustagi, M., Iyer, A., Comb, M., White, M. A., Minna, J. D. & Califano, A., Jan 1 2019, In : PLoS One. 14, 1, e0208646.

Research output: Contribution to journalArticle

Proteome
Electric network analysis
proteome
adenocarcinoma
lungs
5 Citations (Scopus)

Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis

Yan, X., Zhang, X., Wang, L., Zhang, R., Pu, X., Wu, S., Li, L., Tong, P., Wang, J., Meng, Q. H., Jensen, V. B., Girard, L., Minna, J. D., Roth, J. A., Swisher, S. G., Heymach, J. V. & Fang, B., Jan 1 2019, In : Cancer Research. 79, 1, p. 125-132 8 p.

Research output: Contribution to journalArticle

Thioredoxin-Disulfide Reductase
Thioredoxins
Glutathione
Lung Neoplasms
Oxidoreductases
6 Citations (Scopus)

LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence inKRAS-mutant lung adenocarcinoma

Galan-Cobo, A., Sitthideatphaiboon, P., Qu, X., Poteete, A., Pisegna, M. A., Tong, P., Chen, P. H., Boroughs, L. K., Rodriguez, M. L. M., Zhang, W., Parlati, F., Wang, J., Gandhi, V., Skoulidis, F., DeBerardinis, R. J., Minna, J. D. & Heymach, J. V., Jan 1 2019, In : Cancer Research. 79, 13, p. 3251-3267 17 p.

Research output: Contribution to journalArticle

Glutamine
Glutaminase
Oxidation-Reduction
NADP
Neoplasms
10 Citations (Scopus)

Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

Rudin, C. M., Poirier, J. T., Byers, L. A., Dive, C., Dowlati, A., George, J., Heymach, J. V., Johnson, J. E., Lehman, J. M., MacPherson, D., Massion, P. P., Minna, J. D., Oliver, T. G., Quaranta, V., Sage, J., Thomas, R. K., Vakoc, C. R. & Gazdar, A. F., Jan 1 2019, In : Nature Reviews Cancer.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
POU Domain Factors
Therapeutic Human Experimentation
Neoplasms
Homeobox Genes

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Hsieh, M. H., Choe, J. H., Gadhvi, J., Kim, Y. J., Arguez, M. A., Palmer, M., Gerold, H., Nowak, C., Do, H., Mazambani, S., Knighton, J. K., Cha, M., Goodwin, J., Kang, M. K., Jeong, J. Y., Lee, S. Y., Faubert, B., Xuan, Z., Abel, E. D., Scafoglio, C. & 11 others, Shackelford, D. B., Minna, J. D., Singh, P. K., Shulaev, V., Bleris, L., Hoyt, K., Kim, J., Inoue, M., DeBerardinis, R. J., Kim, T. H. & Kim, J. W., Aug 13 2019, In : Cell Reports. 28, 7, p. 1860-1878.e9

Research output: Contribution to journalArticle

Open Access
Ketogenic Diet
Squamous Cell Carcinoma
Glucose
Neoplasms
SOXB1 Transcription Factors
1 Citation (Scopus)

Small cell lung cancers made from scratch

Gazdar, A. F. & Minna, J. D., Mar 1 2019, In : Journal of Experimental Medicine. 216, 3, p. 476-478 3 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Small Cell Lung Carcinoma
Pluripotent Stem Cells
Lung
Therapeutics

Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells

Wang, X. D., Hu, R., Ding, Q., Savage, T. K., Huffman, K. E., Williams, N. S., Cobb, M. H., Minna, J. D., Johnson, J. E. & Yu, Y., Dec 1 2019, In : Nature communications. 10, 1, 3201.

Research output: Contribution to journalArticle

Open Access
Neuroendocrine Cells
Neuroendocrine Tumors
Small Cell Lung Carcinoma
Tumors
Lung Neoplasms
1 Citation (Scopus)

Systematic analysis of gene expression in lung adenocarcinoma and squamous cell carcinoma with a case study of FAM83A and FAM83B

Cai, L., Luo, D., Yao, B., Yang, D. M., Lin, S., Girard, L., DeBerardinis, R. J., Minna, J. D., Xie, Y. & Xiao, G., Jun 1 2019, In : Cancers. 11, 6, 886.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Lung Neoplasms
Gene Expression
Databases
Neoplasm Genes

Unbiased peptoid combinatorial cell screen identifies plectin protein as a potential biomarker for lung cancer stem cells

Raymond, A. C., Gao, B., Girard, L., Minna, J. D. & Gomika Udugamasooriya, D., Dec 1 2019, In : Scientific reports. 9, 1, 14954.

Research output: Contribution to journalArticle

Open Access
Plectin
Peptoids
Neoplastic Stem Cells
Lung Neoplasms
Biomarkers

Validation of the 12-gene predictive signature for adjuvant chemotherapy response in lung cancer

Xie, Y., Lu, W., Wang, S., Tang, X., Tang, H., Zhou, Y., Moran, C., Behrens, C., Roth, J. A., Zhou, Q., Johnson, D. H., Swisher, S. G., Heymach, J. V., Papadimitrakopoulou, V. A., Xiao, G., Minna, J. D. & Wistuba, I. I., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Lung Neoplasms
Genes
Non-Small Cell Lung Carcinoma
Paraffin
2018
1 Citation (Scopus)

A quantitative method for assessing smoke associated molecular damage in lung cancers

Song, K., Bi, J. H., Qiu, Z. W., Felizardo, R., Girard, L., Minna, J. D. & Gazdar, A. F., Jan 1 2018, In : Translational Lung Cancer Research. 7, 4, p. 439-449 11 p.

Research output: Contribution to journalArticle

Smoke
Tobacco
Lung Neoplasms
Mutation
Small Cell Lung Carcinoma
13 Citations (Scopus)

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

Lung Neoplasms
Neoplasms
Oncology
Biosynthesis
Small Molecule Libraries
2 Citations (Scopus)

Concomitant targeting of the mTOR/MAPK pathways: Novel therapeutic strategy in subsets of RICTOR/KRAS-altered non-small cell lung cancer

Ruder, D., Papadimitrakopoulou, V., Shien, K., Behrens, C., Kalhor, N., Chen, H., Shen, L., Jack Lee, J., Hong, W. K., Tang, X., Girard, L., Minna, J. D., Diao, L., Wang, J., Mino, B., Villalobos, P., Rodriguez-Canales, J., Hanson, N. E., Sun, J., Miller, V. & 6 others, Greenbowe, J., Frampton, G., Herbst, R. S., Baladandayuthapani, V., Wistuba, I. I. & Izzo, J. G., Sep 1 2018, In : Oncotarget. 9, 74, p. 33995-34008 14 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Biodiversity
Therapeutics
Lung Neoplasms
Clinical Trials
1 Citation (Scopus)

Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors

Pozo, K., Kelenis, D. P., Minna, J. D. & Johnson, J. E., Oct 1 2018, In : Cancer Discovery. 8, 10, p. 1216-1218 3 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Lung
Lung Neoplasms
Neoplasms
Histology

eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer

Tanaka, I., Sato, M., Kato, T., Goto, D., Kakumu, T., Miyazawa, A., Yogo, N., Hase, T., Morise, M., Sekido, Y., Girard, L., Minna, J. D., Byers, L. A., Heymach, J. V., Coombes, K. R., Kondo, M. & Hasegawa, Y., Jan 1 2018, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Peptide Initiation Factors
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Small Interfering RNA
2 Citations (Scopus)

Estrogen receptor beta-mediated modulation of lung cancer cell proliferation by 27-hydroxycholesterol

Hiramitsu, S., Ishikawa, T., Lee, W. R., Khan, T., Crumbley, C., Khwaja, N., Zamanian, F., Asghari, A., Sen, M., Zhang, Y., Hawse, J. R., Minna, J. D. & Umetani, M., Aug 23 2018, In : Frontiers in Endocrinology. 9, AUG, 470.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Lung Neoplasms
Cell Proliferation
Estrogen Receptors
27-hydroxycholesterol
5 Citations (Scopus)

HORMAD1 is a negative prognostic indicator in lung adenocarcinoma and specifies resistance to oxidative and genotoxic stress

Nichols, B. A., Oswald, N. W., McMillan, E. A., McGlynn, K., Yan, J., Kim, M. S., Saha, J., Mallipeddi, P. L., LaDuke, S. A., Villalobos, P. A., Rodriguez-Canales, J., Wistuba, I. I., Posner, B. A., Davis, A. J., Minna, J. D., MacMillan, J. B. & Whitehurst, A. W., Nov 1 2018, In : Cancer Research. 78, 21, p. 6196-6208 13 p.

Research output: Contribution to journalArticle

DNA Damage
Oxidative Stress
Homologous Recombination
Testicular Neoplasms
Neoplasms
3 Citations (Scopus)

Identifying a missing lineage driver in a subset of lung neuroendocrine tumors

Pozo, K., Minna, J. D. & Johnson, J. E., Jul 1 2018, In : Genes and Development. 32, 13-14, p. 865-867 3 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Lung
Neoplasms
Small Cell Lung Carcinoma
Transcription Factors
12 Citations (Scopus)

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

Huang, F., Ni, M., Chalishazar, M. D., Huffman, K. E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L. G., Ireland, A. S., Li, K., Gu, W., Kaushik, A. K., Liu, X., Gazdar, A. F., Oliver, T. G., Minna, J. D., Hu, Z. & DeBerardinis, R. J., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Inosine Monophosphate
Small Cell Lung Carcinoma
Oxidoreductases
Guanosine
Nucleotides

Kub5-HeraRPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers

Motea, E. A., Fattah, F. J., Xiao, L., Girard, L., Rommel, A., Morales, J. C., Patidar, P., Zhou, Y., Porter, A., Xie, Y., Minna, J. D. & Boothman, D. A., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6459-6470 12 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Precision Medicine
Breast Neoplasms
DNA Damage
CDC2 Protein Kinase
3 Citations (Scopus)

LCE: an open web portal to explore gene expression and clinical associations in lung cancer

Cai, L., Lin, S. Y., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A. F., Heymach, J., Wistuba, I., Xiao, G., Minna, J. D. & Xie, Y., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Lung Neoplasms
Gene Expression
Databases
Survival Analysis
Meta-Analysis
1 Citation (Scopus)

LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer

Du, L., Zhao, Z., Suraokar, M., Shelton, S. S., Ma, X., Hsiao, T. H., Minna, J. D., Wistuba, I. & Pertsemlidis, A., Jul 1 2018, In : Oncotarget. 9, 51, p. 29601-29618 18 p.

Research output: Contribution to journalArticle

Oncogenes
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Small Cell Lung Carcinoma
Neuroendocrine Cells
1 Citation (Scopus)

Silencing the snail-dependent RNA splice regulator ESRP1 drives malignant transformation of human pulmonary epithelial cells

Walser, T. C., Jing, Z., Tran, L. M., Lin, Y. Q., Yakobian, N., Wang, G., Krysan, K., Zhu, L. X., Sharma, S., Lee, M. H., Belperio, J. A., Ooi, A. T., Gomperts, B. N., Shay, J. W., Larsen, J. E., Minna, J. D., Hong, L. S., Fishbein, M. C. & Dubinett, S. M., Apr 15 2018, In : Cancer Research. 78, 8, p. 1986-1999 14 p.

Research output: Contribution to journalArticle

Snails
Epithelial Cells
RNA
Lung
Non-Small Cell Lung Carcinoma
13 Citations (Scopus)

Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes

Zhang, W., Girard, L., Zhang, Y. A., Haruki, T., Papari-Zareei, M., Stastny, V., Ghayee, H. K., Pacak, K., Oliver, T. G., Minna, J. D. & Gazdar, A. F., Feb 1 2018, In : Translational Lung Cancer Research. 7, 1, p. 32-49 18 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Phenotype
Neoplasms
Tumor Cell Line
Cell Line
4 Citations (Scopus)

Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance

Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T. P., Batten, K., Cornelius, C., Dalvi, M. P., Ramirez, M., Du, W., Wu, L. F., Altschuler, S. J., Brekken, R., Martinez, E. D., Minna, J. D., Wright, W. E. & Shay, J. W., Aug 1 2018, In : Neoplasia (United States). 20, 8, p. 826-837 12 p.

Research output: Contribution to journalArticle

alpha-2'-deoxythioguanosine
Telomerase
Non-Small Cell Lung Carcinoma
Drug Therapy
Lung Neoplasms
4 Citations (Scopus)

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors

He, M., Liu, S., Gallolu Kankanamalage, S., Borromeo, M. D., Girard, L., Gazdar, A. F., Minna, J. D., Johnson, J. E. & Cobb, M. H., Apr 1 2018, In : Translational Oncology. 11, 2, p. 292-299 8 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Neuroendocrine Tumors
Small Cell Lung Carcinoma
Lung
Lung Neoplasms
46 Citations (Scopus)

The impact of smoking and tp53 mutations in lung adenocarcinoma patients with targetable mutations—the lung cancer mutation consortium (LCMC2)

Aisner, D. L., Sholl, L. M., Berry, L. D., Rossi, M. R., Chen, H., Fujimoto, J., Moreira, A. L., Ramalingam, S. S., Villaruz, L. C., Otterson, G. A., Haura, E., Politi, K., Glisson, B., Cetnar, J., Garon, E. B., Schiller, J., Waqar, S. N., Sequist, L. V., Brahmer, J., Shyr, Y. & 7 others, Kugler, K., Wistuba, I. I., Johnson, B. E., Minna, J. D., Kris, M. G., Bunn, P. A. & Kwiatkowski, D. J., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1038-1047 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Smoking
Mutation
High-Throughput Nucleotide Sequencing
Survival
8 Citations (Scopus)

TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer

Gong, K., Guo, G., Gerber, D. E., Gao, B., Peyton, M., Huang, C., Minna, J. D., Hatanpaa, K. J., Kernstine, K., Cai, L., Xie, Y., Zhu, H., Fattah, F. J., Zhang, S., Takahashi, M., Mukherjee, B., Burma, S., Dowell, J., Dao, K., Papadimitrakopoulou, V. A. & 4 others, Olivas, V., Bivona, T. G., Zhao, D. & Habib, A. A., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2500-2518 19 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
RNA Stability
Inflammation Mediators
Oncogenes

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

Updegraff, B. L., Zhou, X., Guo, Y., Padanad, M. S., Chen, P. H., Yang, C., Sudderth, J., Rodriguez-Tirado, C., Girard, L., Minna, J. D., Mishra, P., DeBerardinis, R. J. & O'Donnell-Mendell, K. A., Jan 1 2018, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

CD147 Antigens
Metabolism
Lactic Acid
Lung Neoplasms
Peptide Hydrolases
2017
42 Citations (Scopus)

Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays

Li, J., Zhao, W., Akbani, R., Liu, W., Ju, Z., Ling, S., Vellano, C. P., Roebuck, P., Yu, Q., Eterovic, A. K., Byers, L. A., Davies, M. A., Deng, W., Gopal, Y. N. V., Chen, G., von Euw, E. M., Slamon, D., Conklin, D., Heymach, J. V., Gazdar, A. F. & 5 others, Minna, J. D., Myers, J. N., Lu, Y., Mills, G. B. & Liang, H., Feb 13 2017, In : Cancer Cell. 31, 2, p. 225-239 15 p.

Research output: Contribution to journalArticle

Protein Array Analysis
Cell Line
Preclinical Drug Evaluations
Neoplasms
Proteins
46 Citations (Scopus)

CHK1 inhibition in small-cell lung cancer produces single-agent activity in biomarker-defined disease subsets and combination activity with cisplatin or olaparib

Sen, T., Tong, P., Stewart, C. A., Cristea, S., Valliani, A., Shames, D. S., Redwood, A. B., Fan, Y. H., Li, L., Glisson, B. S., Minna, J. D., Sage, J., Gibbons, D. L., Piwnica-Worms, H., Heymach, J. V., Wang, J. & Byers, L. A., Jul 15 2017, In : Cancer Research. 77, 14, p. 3870-3884 15 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Cisplatin
Biomarkers
Platinum
RNA Interference
8 Citations (Scopus)

Combination therapy targeting BCL6 and phospho-STAT3 defeats intratumor heterogeneity in a subset of non-small cell lung cancers

Deb, D., Rajaram, S., Larsen, J. E., Dospoy, P. D., Marullo, R., Li, L. S., Avila, K., Xue, F., Cerchietti, L., Minna, J. D., Altschuler, S. J. & Wu, L. F., Jun 1 2017, In : Cancer Research. 77, 11, p. 3070-3081 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Oncogenes
Down-Regulation
Neoplasms
MAP Kinase Signaling System
51 Citations (Scopus)

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

Carbamyl Phosphate
Ligases
Lung Neoplasms
DNA
Ammonia
3 Citations (Scopus)

Genetic variations in cancer-related significantly mutated genes and lung cancer susceptibility

Zhang, Y., Zhang, L., Li, R., Chang, D. W., Ye, Y., Minna, J. D., Roth, J. A., Han, B. & Wu, X., Jul 1 2017, In : Annals of oncology : official journal of the European Society for Medical Oncology. 28, 7, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Single Nucleotide Polymorphism
Genes
Atlases
Neoplasms
2 Citations (Scopus)

Identification of a human airway epithelial cell subpopulation with altered biophysical, molecular, and metastatic properties

Pagano, P. C., Tran, L. M., Bendris, N., O'Byrne, S., Tse, H. T., Sharma, S., Hoech, J. W., Park, S. J., Liclican, E. L., Jing, Z., Li, R., Krysan, K., Paul, M. K., Fontebasso, Y., Larsen, J. E., Hakimi, S., Seki, A., Fishbein, M. C., Gimzewski, J. K., Di Carlo, D. & 3 others, Minna, J. D., Walser, T. C. & Dubinett, S. M., Sep 1 2017, In : Cancer Prevention Research. 10, 9, p. 514-524 11 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Epithelial Cells
Lung Neoplasms
Cell Line
Lung
2 Citations (Scopus)

Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer

Kakumu, T., Sato, M., Goto, D., Kato, T., Yogo, N., Hase, T., Morise, M., Fukui, T., Yokoi, K., Sekido, Y., Girard, L., Minna, J. D., Byers, L. A., Heymach, J. V., Coombes, K. R., Kondo, M. & Hasegawa, Y., Apr 1 2017, In : Cancer Science. 108, 4, p. 732-743 12 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Catalytic Domain
Proteasome Endopeptidase Complex
Cell Line
Small Interfering RNA
11 Citations (Scopus)

JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non–small cell lung cancer

Shien, K., Papadimitrakopoulou, V. A., Ruder, D., Behrens, C., Shen, L., Kalhor, N., Song, J., Lee, J. J., Wang, J., Tang, X., Herbst, R. S., Toyooka, S., Girard, L., Minna, J. D., Kurie, J. M., Wistuba, I. I. & Izzo, J. G., Oct 1 2017, In : Molecular Cancer Therapeutics. 16, 10, p. 2234-2245 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cytokines
Interleukin-6
Pharmaceutical Preparations
Oncostatin M
5 Citations (Scopus)

Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions

Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J. R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J. K., Rix, U., Le, A. T., Aisner, D. L., Varella-Garcia, M., Doebele, R. C. & 10 others, Covington, K. R., Hampton, O. A., Doddapaneni, H. V., Jayaseelan, J. C., Hu, J., Wheeler, D. A., Shay, J. W., Rimm, D. L., Gazdar, A. & Minna, J. D., 2017, In : Oncotarget. 8, 7, p. 11114-11126 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epithelial Cells
Cell Culture Techniques
Neoplasms
Lung
18 Citations (Scopus)

Proportion of Never-Smoker Non-Small Cell Lung Cancer Patients at Three Diverse Institutions

Pelosof, L., Ahn, C., Gao, A., Horn, L., Madrigales, A., Cox, J., McGavic, D., Minna, J. D., Gazdar, A. F. & Schiller, J., Jul 1 2017, In : Journal of the National Cancer Institute. 109, 7, djw295.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Small Cell Lung Carcinoma
Registries
Logistic Models
14 Citations (Scopus)

PROTOCADHERIN 7 acts through SET and PP2A to potentiate MAPK signaling by EGFR and KRAS during lung tumorigenesis

Zhou, X., Updegraff, B. L., Guo, Y., Peyton, M., Girard, L., Larsen, J. E., Xie, X-J., Zhou, Y., Hwang, T. H., Xie, Y., Rodriguez-Canales, J., Villalobos, P., Behrens, C., Wistuba, I. I., Minna, J. D. & O'Donnell-Mendell, K. A., Jan 1 2017, In : Cancer Research. 77, 1, p. 187-197 11 p.

Research output: Contribution to journalArticle

Carcinogenesis
Non-Small Cell Lung Carcinoma
Lung
Neoplasms
Phosphoprotein Phosphatases
5 Citations (Scopus)

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer

Zhao, X., Huffman, K. E., Fujimoto, J., Canales, J. R., Girard, L., Nie, G., Heymach, J. V., Wistuba, I. I., Minna, J. D. & Yu, Y., Oct 1 2017, In : Journal of the American Society for Mass Spectrometry. 28, 10, p. 2078-2089 12 p.

Research output: Contribution to journalArticle

Large-Core Needle Biopsy
Biopsy
Needles
Proteomics
Lung Neoplasms
20 Citations (Scopus)

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Tagal, V., Wei, S., Zhang, W., Brekken, R. A., Posner, B. A., Peyton, M., Girard, L., Hwang, T., Wheeler, D. A., Minna, J. D., White, M. A., Gazdar, A. F. & Roth, M. G., Jan 19 2017, In : Nature Communications. 8, 14098.

Research output: Contribution to journalArticle

Aurora Kinase A
mutations
Non-Small Cell Lung Carcinoma
lungs
inhibitors
27 Citations (Scopus)

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

Dalvi, M. P., Wang, L., Zhong, R., Kollipara, R. K., Park, H., Bayo, J., Yenerall, P., Zhou, Y., Timmons, B. C., Rodriguez-Canales, J., Behrens, C., Mino, B., Villalobos, P., Parra, E. R., Suraokar, M., Pataer, A., Swisher, S. G., Kalhor, N., Bhanu, N. V., Garcia, B. A. & 9 others, Heymach, J. V., Coombes, K., Xie, Y., Girard, L., Gazdar, A. F., Kittler, R., Wistuba, I. I., Minna, J. D. & Martinez, E. D., May 23 2017, In : Cell Reports. 19, 8, p. 1669-1684 16 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Hypersensitivity
Chemotherapy
Cells
Non-Small Cell Lung Carcinoma
36 Citations (Scopus)

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Goodwin, J., Neugent, M. L., Lee, S. Y., Choe, J. H., Choi, H., Enkins, D. M. R. J., Ruthenborg, R. J., Robinson, M. W., Jeong, J. Y., Wake, M., Abe, H., Takeda, N., Endo, H., Inoue, M., Xuan, Z., Yoo, H., Chen, M., Ahn, J. M., Minna, J. D., Helke, K. L. & 3 others, Singh, P. K., Shackelford, D. B. & Kim, J. W., May 26 2017, In : Nature Communications. 8, 15503.

Research output: Contribution to journalArticle

phenotype
vulnerability
Non-Small Cell Lung Carcinoma
lungs
Squamous Cell Carcinoma
2016
36 Citations (Scopus)

An expression signature as an aid to the histologic classification of non-small cell lung cancer

Girard, L., Rodriguez-Canales, J., Behrens, C., Thompson, D. M., Botros, I. W., Tang, H., Xie, Y., Rekhtman, N., Travis, W. D., Wistuba, I. I., Minna, J. D. & Gazdar, A. F., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4880-4889 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Squamous Cell Carcinoma
Adenocarcinoma
Atlases
Lung
69 Citations (Scopus)

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H. & Johnson, J. E., Aug 2 2016, In : Cell Reports. 16, 5, p. 1259-1272 14 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Small Cell Lung Carcinoma
Tumors
Genes
Lung

A statistical method for detecting differentially expressed SNVs based on next-generation RNA-seq data

Fu, R., Wang, P., Ma, W., Taguchi, A., Wong, C. H., Zhang, Q., Gazdar, A., Hanash, S. M., Zhou, Q., Zhong, H. & Feng, Z., 2016, (Accepted/In press) In : Biometrics.

Research output: Contribution to journalArticle

Nucleotides
RNA
Statistical method
Tumors
Statistical methods