• 71926 Citations
  • 119 h-Index
1984 …2020

Research output per year

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Research Output

Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models

Fujiki, N., Yoshida, Y., Zhang, S., Sakurai, T., Yanagisawa, M. & Nishino, S., Sep 1 2006, In : Peptides. 27, 9, p. 2326-2331 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice

Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M. & Kim, C. H., Aug 2013, In : Gastroenterology. 145, 2, p. 396-406.e10

Research output: Contribution to journalArticle

283 Scopus citations

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M. & Yanagisawa, M., Jan 27 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 4, p. 1045-1050 6 p.

Research output: Contribution to journalArticle

403 Scopus citations

Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice

Clouthier, D. E., Williams, S. C., Yanagisawa, H., Wieduwilt, M., Richardson, J. A. & Yanagisawa, M., Jan 1 2000, In : Developmental Biology. 217, 1, p. 10-24 15 p.

Research output: Contribution to journalArticle

159 Scopus citations

Similarity of endothelin to snake venom toxin [9]

Takasaki, C., Yanagisawa, M., Kimura, S., Goto, K. & Masaki, T., Jan 1 1988, In : Nature. 335, 6188, 1 p.

Research output: Contribution to journalLetter

55 Scopus citations

Sleep, feeding, and neuropeptides: Roles of orexins and orexin receptors

Mieda, M. & Yanagisawa, M., Jun 1 2002, In : Current Opinion in Neurobiology. 12, 3, p. 339-345 7 p.

Research output: Contribution to journalReview article

84 Scopus citations

Sleep/Wake Behaviors in Mice during Pregnancy and Pregnancy-Associated Hypertensive Mice

Komiya, H., Miyoshi, C., Iwasaki, K., Hotta-Hirashima, N., Ikkyu, A., Kanno, S., Honda, T., Gosho, M., Hamada, H., Satoh, T., Fukamizu, A., Funato, H. & Yanagisawa, M., Mar 1 2018, In : Sleep. 41, 3

Research output: Contribution to journalArticle

2 Scopus citations

Sleep State Analysis Using Calcium Imaging Data by Non-negative Matrix Factorization

Nagayama, M., Aritake, T., Hino, H., Kanda, T., Miyazaki, T., Yanagisawa, M., Akaho, S. & Murata, N., Jan 1 2019, Artificial Neural Networks and Machine Learning – ICANN 2019: Theoretical Neural Computation - 28th International Conference on Artificial Neural Networks, 2019, Proceedings. Tetko, I. V., Karpov, P., Theis, F. & Kurková, V. (eds.). Springer Verlag, p. 102-113 12 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11727 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice

Iguchi, H., Ikeda, Y., Okamura, M., Tanaka, T., Urashima, Y., Ohguchi, H., Takayasu, S., Kojima, N., Iwasaki, S., Ohashi, R., Jiang, S., Hasegawa, G., Ioka, R. X., Magoori, K., Sumi, K., Maejima, T., Uchida, A., Naito, M., Osborne, T. F., Yanagisawa, M. & 3 others, Yamamoto, T. T., Kodama, T. & Sakai, J., Nov 11 2005, In : Journal of Biological Chemistry. 280, 45, p. 37669-37680 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Structure-activity relationships of endothelin: Importance of the C-terminal moiety

Kimura, S., Kasuya, Y., Sawamura, T., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. & Masaki, T., Nov 15 1988, In : Biochemical and Biophysical Research Communications. 156, 3, p. 1182-1186 5 p.

Research output: Contribution to journalArticle

206 Scopus citations

Structure and function of human prepro-orexin gene

Sakurai, T., Moriguchi, T., Furuya, K., Kajiwara, N., Nakamura, T., Yanagisawa, M. & Goto, K., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17771-17776 6 p.

Research output: Contribution to journalArticle

162 Scopus citations

Studies on endothelium-dependent vasorelaxation by hydralazine in porcine coronary artery

Wei, S., Kasuya, Y., Yanagisawa, M., Kimura, S., Masaki, T. & Goto, K., Mar 5 1997, In : European Journal of Pharmacology. 321, 3, p. 307-314 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Study on the Endothelin Gene and its Expression

Masaki, T., Yanagisawa, M., Inoue, A., Kimura, S. & Goto, K., Jan 1 1990, In : JAPANESE CIRCULATION JOURNAL. 54, 9, p. 1221-1225 5 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Systemic hypertension induced by hepatic overexpression of human preproendothelin-1 in rats

Niranjan, V., Télémaque, S., De Wit, D., Gerard, R. D. & Yanagisawa, M., Nov 15 1996, In : Journal of Clinical Investigation. 98, 10, p. 2364-2372 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

TaqI polymorphism at the human preproendothelin-1 gene (EDN1)

Watanabe, M., Yanagisawa, M., Hamaguchi, H., Kanazawa, I. & Masaki, T., Sep 25 1991, In : Nucleic acids research. 19, 18, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

Hosoda, K., Hammer, R. E., Richardson, J. A., Baynash, A. G., Cheung, J. C., Giaid, A. & Yanagisawa, M., Dec 30 1994, In : Cell. 79, 7, p. 1267-1276 10 p.

Research output: Contribution to journalArticle

830 Scopus citations

T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

Shinagawa, S., Okazaki, T., Ikeda, M., Yudoh, K., Kisanuki, Y. Y., Yanagisawa, M., Kawahata, K. & Ozaki, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14500.

Research output: Contribution to journalArticle

4 Scopus citations

The development of hypocretin (OREXIN) deficiency in hypocretin/ataxin-3 transgenic rats

Zhang, S., Lin, L., Kaur, S., Thankachan, S., Blanco-Centurion, C., Yanagisawa, M., Mignot, E. & Shiromani, P. J., Aug 10 2007, In : Neuroscience. 148, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker

Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K. & Yanagisawa, M., Aug 8 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 32, p. 12150-12155 6 p.

Research output: Contribution to journalArticle

218 Scopus citations

The embryo makes red blood cell progenitors in every tissue simultaneously with blood vessel morphogenesis

Sequeira Lopez, M. L. S., Cherñavvsky, D. R., Nomasa, T., Wall, L., Yanagisawa, M. & Gomez, R. A., Apr 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 284, 4 53-4, p. R1126-R1137

Research output: Contribution to journalArticle

44 Scopus citations

The endothelin system: A new target for therapeutic intervention

Yanagisawa, M., Jan 1 1994, In : Circulation. 89, 3, p. 1320-1322 3 p.

Research output: Contribution to journalEditorial

Open Access
183 Scopus citations

The expression pattern of endothelin 3 in the avian embryo

Nataf, V., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., May 1 1998, In : Mechanisms of Development. 73, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo

Nataf, V., Grapin-Botton, A., Champeval, D., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., Jul 1998, In : Mechanisms of Development. 75, 1-2, p. 145-149 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes

Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K. & Masaki, T., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 8, p. 2863-2867 5 p.

Research output: Contribution to journalArticle

Open Access
2459 Scopus citations

The human endothelin family: cDNA cloning, complete primary structure and differential tissue expression of the three precursors

Yanagtsawa, M., Inoue, A., Imai, T., Matsushita, Y. & Masaki, T., Jul 5 1990, In : European Journal of Pharmacology. 183, 5, p. 1628-1629 2 p.

Research output: Contribution to journalArticle

The human preproendothelin-1 gene: Possible regulation by endothelial phosphoinositide turnover signaling

Yanagisawa, M., Inoue, A., Takuwa, Y., Mitsui, Y., Kobayashi, M. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S13-S17

Research output: Contribution to journalArticle

144 Scopus citations

The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression

Inoue, A., Yanagisawa, M., Takuwa, Y., Mitsui, Y., Kobayashi, M. & Masaki, T., Jan 1 1989, In : Journal of Biological Chemistry. 264, 25, p. 14954-14959 6 p.

Research output: Contribution to journalArticle

388 Scopus citations

The ligand-receptor interactions of the endothelin systems are mediated by distinct 'message' and 'address' domains

Sakamoto, A., Yanagisawa, M., Sakurai, T., Nakao, K., Toyo-oka, T., Yano, M. & Masaki, T., Dec 1 1993, In : Journal of Cardiovascular Pharmacology. 22, SUPPL. 8, p. S113-S116

Research output: Contribution to journalArticle

13 Scopus citations

The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57Bl/6J mice

Kelly, M. A., Low, M. J., Phillips, T. J., Wakeland, E. K. & Yanagisawa, M., Oct 1 2003, In : Mammalian Genome. 14, 10, p. 692-702 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S. G., Yanagisawa, M., Elmquist, J. K., Nestler, E. J. & Zigman, J. M., Jul 1 2008, In : Nature neuroscience. 11, 7, p. 752-753 2 p.

Research output: Contribution to journalArticle

380 Scopus citations

The possible role of endothelin-1 in the pathogenesis of coronary vasospasm

Kurihara, H., Yoshizumi, M., Sugiyama, T., Yamaoki, K., Nagai, R., Takaku, F., Satoh, H., Inui, J., Yanagisawa, M., Masaki, T. & Yazaki, Y., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S132-S137

Research output: Contribution to journalArticle

81 Scopus citations

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

Vicent, D., Ilany, J., Kondo, T., Naruse, K., Fisher, S. J., Kisanuki, Y. Y., Bursell, S., Yanagisawa, M., King, G. L. & Kahn, C. R., May 2003, In : Journal of Clinical Investigation. 111, 9, p. 1373-1380 8 p.

Research output: Contribution to journalArticle

Open Access
267 Scopus citations

The second tomoh masaki award (2013)

Emoto, N., Kasuya, Y. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 87-90 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

The thirteenth international conference on endothelin (ET-13), Tokyo, 2013

Emoto, N. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 70-76 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J. I., Williams, S. C., Richardson, J. A. & Yanagisawa, M., Feb 15 2001, In : Developmental Biology. 230, 2, p. 230-242 13 p.

Research output: Contribution to journalArticle

786 Scopus citations

Timed inhibition of orexin system by suvorexant improved sleep and glucose metabolism in type 2 diabetic db/db mice

Tsuneki, H., Kon, K., Ito, H., Yamazaki, M., Takahara, S., Toyooka, N., Ishii, Y., Sasahara, M., Wada, T., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Nov 1 2016, In : Endocrinology. 157, 11, p. 4146-4157 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Tissue-specific modulation of endothelin receptors in a rat model of hypertension

Telemaque-Potts, S., Kuc, R. E., Yanagisawa, M. & Davenport, A. P., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S122-S123

Research output: Contribution to journalArticle

5 Scopus citations

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

Willie, J. T., Chemelli, R. M., Sinton, C. M. & Yanagisawa, M., Aug 11 2001, In : Annual Review of Neuroscience. 24, p. 429-458 30 p.

Research output: Contribution to journalReview article

607 Scopus citations

Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain

Giaid, A., Gibson, S. J., Herrero, M. T., Gentleman, S., Legon, S., Yanagisawa, M., Masaki, T., Ibrahim, N. B. N., Roberts, G. W., Rossi, M. L. & Polak, J. M., Jan 1 1991, In : Histochemistry. 95, 3, p. 303-314 12 p.

Research output: Contribution to journalArticle

146 Scopus citations

Toward the mysteries of sleep

Yanagisawa, M., Jan 1 2019, In : Keio Journal of Medicine. 68, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells

Kurihara, H., Yoshizumi, M., Sugiyama, T., Takaku, F., Yanagisawa, M., Masaki, T., Hamaoki, M., Kato, H. & Yazaki, Y., Mar 31 1989, In : Biochemical and Biophysical Research Communications. 159, 3, p. 1435-1440 6 p.

Research output: Contribution to journalArticle

370 Scopus citations
Open Access
145 Scopus citations

Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice

Rice, J., Doggett, B., Sweetser, D. A., Yanagisawa, H., Yanagisawa, M. & Kapur, R. P., Jan 19 2000, In : Developmental Dynamics. 217, 1, p. 120-132 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Transient expression of neuropeptide W in postnatal mouse hypothalamus - A putative regulator of energy homeostasis

Motoike, T., Skach, A. G., Godwin, J. K., Sinton, C. M., Yamazaki, M., Abe, M., Natsume, R., Sakimura, K. & Yanagisawa, M., Aug 1 2015, In : Neuroscience. 301, p. 323-337 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction

Kaushik, M. K., Kaul, S. C., Wadhwa, R., Yanagisawa, M. & Urade, Y., Feb 2017, In : PloS one. 12, 2, e0172508.

Research output: Contribution to journalArticle

8 Scopus citations

Two different forms of endothelin receptors in rat lung

Masuda, Y., Miyazaki, H., Kondoh, M., Watanabe, H., Yanagisawa, M., Masaki, T. & Murakami, K., Nov 6 1989, In : FEBS Letters. 257, 2, p. 208-210 3 p.

Research output: Contribution to journalArticle

107 Scopus citations
111 Scopus citations

Two distinct types of endothelin receptors are present on chick cardiac membranes

Watanabe, H., Miyazaki, H., Kondoh, M., Masuda, Y., Kimura, S., Yanagisawa, M., Masaki, T. & Murakami, K., Jun 30 1989, In : Biochemical and Biophysical Research Communications. 161, 3, p. 1252-1259 8 p.

Research output: Contribution to journalArticle

164 Scopus citations

Two isoforms of smooth muscle myosin regulatory light chain in chicken gizzard

Inoue, A., Yanagisawa, M., Takano-Ohmuro, H. & Masaki, T., Aug 1989, In : European Journal of Biochemistry. 183, 3, p. 645-651 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Two problems on smooth muscle contraction in relation to calcium ion

Masaki, T., Yanagisawa, M., Kurihara, H., Goto, K., Kimura, S., Katoch, S. & Tanaka, T., Jan 1 1989, In : Journal of Pharmacobio-Dynamics. 12, 4, p. S-105

Research output: Contribution to journalArticle