• 71926 Citations
  • 119 h-Index
1984 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2003

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Tanaka, H., Yoshida, T., Miyamoto, N., Motoike, T., Kurosu, H., Shibata, K., Yamanaka, A., Williams, S. C., Richardson, J. A., Tsujino, N., Garry, M. G., Lerner, M. R., King, D. S., O'Dowd, B. F., Sakurai, T. & Yanagisawa, M., May 13 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 10, p. 6251-6256 6 p.

Research output: Contribution to journalArticle

142 Scopus citations

Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats

Torrealba, F., Yanagisawa, M. & Saper, C. B., Jul 16 2003, In : Neuroscience. 119, 4, p. 1033-1044 12 p.

Research output: Contribution to journalArticle

148 Scopus citations

dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development

Ruest, L. B., Dager, M., Yanagisawa, H., Charité, J., Hammer, R. E., Olson, E. N., Yanagisawa, M. & Clouthier, D. E., May 15 2003, In : Developmental Biology. 257, 2, p. 263-277 15 p.

Research output: Contribution to journalArticle

34 Scopus citations

Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: Molecular genetic dissection of non-REM and REM sleep regulatory processes

Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., Marcus, J. N., Lee, C., Elmquist, J. K., Kohlmeier, K. A., Leonard, C. S., Richardson, J. A., Hammer, R. E. & Yanagisawa, M., Jun 5 2003, In : Neuron. 38, 5, p. 715-730 16 p.

Research output: Contribution to journalArticle

464 Scopus citations

Dlx5/6-Enhancer Directed Expression of Cre Recombinase in the Pharyngeal Arches and Brain

Ruest, L. B., Hammer, R. E., Yanagisawa, M. & Clouthier, D. E., Dec 1 2003, In : Genesis. 37, 4, p. 188-194 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis

Morishima, M., Yanagisawa, H., Yanagisawa, M. & Baldini, A., Sep 1 2003, In : Developmental Dynamics. 228, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of orexin (hypocretin) on GIRK channels

Hoang, Q. V., Bajic, D., Yanagisawa, M., Nakajima, S. & Nakajima, Y., Aug 1 2003, In : Journal of neurophysiology. 90, 2, p. 693-702 10 p.

Research output: Contribution to journalArticle

71 Scopus citations

G protein-coupled receptor genes in the FANTOM2 database

Kawasawa, Y., McKenzie, L. M., Hill, D. P., Bono, H., Arakawa, T., Carninci, P., Kawai, J., Hayashizaki, Y. & Yanagisawa, M., Jun 1 2003, In : Genome Research. 13, 6 B, p. 1466-1477 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Hypothalamic orexin neurons regulate arousal according to energy balance in mice

Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K. I., Sugiyama, F., Goto, K., Yanagisawa, M. & Sakurai, T., Jun 5 2003, In : Neuron. 38, 5, p. 701-713 13 p.

Research output: Contribution to journalArticle

645 Scopus citations

Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal

Georgescu, D., Zachariou, V., Barrot, M., Mieda, M., Willie, J. T., Eisch, A. J., Yanagisawa, M., Nestler, E. J. & DiLeone, R. J., Apr 15 2003, In : Journal of Neuroscience. 23, 8, p. 3106-3111 6 p.

Research output: Contribution to journalArticle

269 Scopus citations

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

Kondo, T., Vicent, D., Suzuma, K., Yanagisawa, M., King, G. L., Holzenberger, M. & Kahn, C. R., Jun 1 2003, In : Journal of Clinical Investigation. 111, 12, p. 1835-1842 8 p.

Research output: Contribution to journalArticle

180 Scopus citations

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

Fujino, T., Asaba, H., Kang, M. J., Ikeda, Y., Sone, H., Takada, S., Kim, D. H., Ioka, R. X., Ono, M., Tomoyori, H., Okubo, M., Murase, T., Kamataki, A., Yamamoto, J., Magoori, K., Takahashi, S., Miyamoto, Y., Oishi, H., Nose, M., Okazaki, M. & 5 others, Usui, S., Imaizumi, K., Yanagisawa, M., Sakai, J. & Yamamoto, T. T., Jan 7 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 1, p. 229-234 6 p.

Research output: Contribution to journalArticle

295 Scopus citations

N-type calcium channel α1B subunit (Cav2.2) Knock-out mice display hyperactivity and vigilance state differences

Beuckmann, C. T., Sinton, C. M., Miyamoto, N., Ino, M. & Yanagisawa, M., Jul 30 2003, In : Journal of Neuroscience. 23, 17, p. 6793-6797 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons

Llewellyn-Smith, I. J., Martin, C. L., Marcus, J. N., Yanagisawa, M., Minson, J. B. & Scammell, T. E., Nov 13 2003, In : Neuroscience Letters. 351, 2, p. 115-119 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

The embryo makes red blood cell progenitors in every tissue simultaneously with blood vessel morphogenesis

Sequeira Lopez, M. L. S., Cherñavvsky, D. R., Nomasa, T., Wall, L., Yanagisawa, M. & Gomez, R. A., Apr 1 2003, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 284, 4 53-4, p. R1126-R1137

Research output: Contribution to journalArticle

44 Scopus citations

The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57Bl/6J mice

Kelly, M. A., Low, M. J., Phillips, T. J., Wakeland, E. K. & Yanagisawa, M., Oct 1 2003, In : Mammalian Genome. 14, 10, p. 692-702 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

Vicent, D., Ilany, J., Kondo, T., Naruse, K., Fisher, S. J., Kisanuki, Y. Y., Bursell, S., Yanagisawa, M., King, G. L. & Kahn, C. R., May 2003, In : Journal of Clinical Investigation. 111, 9, p. 1373-1380 8 p.

Research output: Contribution to journalArticle

Open Access
267 Scopus citations
2002

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bono, H., Kondo, S., Nikaido, I., Osato, N., Saito, R., Suzuki, H., Yamanaka, I., Kiyosawa, H., Yagi, K., Tomaru, Y., Hasegawa, Y., Nogami, A., Schönbach, C., Gojobori, T., Baldarelli, R., Hill, D. P. & 117 others, Bult, C., Hume, D. A., Quackenbush, J., Schriml, L. M., Kanapin, A., Matsuda, H., Batalov, S., Beisel, K. W., Blake, J. A., Bradt, D., Brusic, V., Chothia, C., Corbani, L. E., Cousins, S., Dalla, E., Dragani, T. A., Fletcher, C. F., Forrest, A., Frazer, K. S., Gaasterland, T., Gariboldi, M., Gissi, C., Godzik, A., Gough, J., Grimmond, S., Gustincich, S., Hirokawa, N., Jackson, I. J., Jarvis, E. D., Kanai, A., Kawaji, H., Kawasawa, Y., Kedzierski, R. M., King, B. L., Konagaya, A., Kurochkin, I. V., Lee, Y., Lenhard, B., Lyons, P. A., Maglott, D. R., Maltais, L., Marchionni, L., McKenzie, L., Miki, H., Nagashima, T., Numata, K., Okido, T., Pavan, W. J., Pertea, G., Pesole, G., Petrovsky, N., Pillai, R., Pontius, J. U., Qi, D., Ramachandran, S., Ravasi, T., Reed, J. C., Reed, D. J., Reid, J., Ring, B. Z., Ringwald, M., Sandelin, A., Schneider, C., Semple, C. A. M., Setou, M., Shimada, K., Sultana, R., Takenaka, Y., Taylor, M. S., Teasdale, R. D., Tomita, M., Verardo, R., Wagner, L., Wahlestedt, C., Wang, Y., Watanabe, Y., Wells, C., Wilming, L. G., Wynshaw-Boris, A., Yanagisawa, M., Yang, I., Yang, L., Yuan, Z., Zavolan, M., Zhu, Y., Zimmer, A., Carninci, P., Hayatsu, N., Hirozane-Kishikawa, T., Konno, H., Nakamura, M., Sakazume, N., Sato, K., Shiraki, T., Waki, K., Kawai, J., Aizawa, K., Arakawa, T., Fukuda, S., Hara, A., Hashizume, W., Imotani, K., Ishii, Y., Itoh, M., Kagawa, I., Miyazaki, A., Sakai, K., Sasaki, D., Shibata, K., Shinagawa, A., Yasunishi, A., Yoshino, M., Waterston, R., Lander, E. S., Rogers, J., Birney, E. & Hayashizaki, Y., Dec 5 2002, In : Nature. 420, 6915, p. 563-573 11 p.

Research output: Contribution to journalArticle

1211 Scopus citations

Blood pressure of endothelin-3 null (-/-) knockout mice and endothelin A receptor null (-/-) knockout mice under anaesthesia

Kuwaki, T., Ishii, T., Ju, K., Yanagisawa, M. & Fukuda, Y., Aug 1 2002, In : Clinical science. 103, SUPPL. 48, p. 48S-52S

Research output: Contribution to journalArticle

11 Scopus citations

Chapter V Orexin receptors

Sakurai, T., Hervieu, G. & Yanagisawa, M., Dec 1 2002, Peptide Receptors Part II. Quirion, R., Bjorklund, A. & Hokfelt, T. (eds.). p. 245-322 78 p. (Handbook of Chemical Neuroanatomy; vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapter

Elevated systemic levels of endothelin-1 and blood pressure correlate with blunted constrictor responses and downregulation of endothelinA, but not endothelinB, receptors in an animal model of hypertension

Télémaque-Potts, S., Kuc, R. E., Maguire, J. J., Ohlstein, E., Yanagisawa, M. & Davenport, A. P., Aug 1 2002, In : Clinical science. 103, SUPPL. 48, p. 357S-362S

Research output: Contribution to journalArticle

14 Scopus citations

ETB receptor protects the tubulointerstitium in experimental thrombotic microangiopathy

Nangaku, M., Yamada, K., Gariepy, C. E., Miyata, T., Inagi, R., Kurokawa, K., Yanagisawa, M., Fujita, T. & Johnson, R. J., Jan 1 2002, In : Kidney international. 62, 3, p. 922-928 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats

Dunbar Ivy, D., Yanagisawa, M., Gariepy, C. E., Gebb, S. A., Colvin, K. L. & McMurtry, I. F., Jul 2 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 4 26-4, p. L703-L712

Research output: Contribution to journalArticle

63 Scopus citations

Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a

Kulathila, R., Clark, K., Savage, P., Bowen, B. R., Emoto, N., Yanagisawa, M. & Jeng, A. Y., Aug 1 2002, In : Clinical science. 103, SUPPL. 48, p. 94S-97S

Research output: Contribution to journalArticle

3 Scopus citations

Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo

Yanagisawa, H., Davist, E. C., Starcher, B. C., Ouchi, T., Yanagisawa, M., Richardson, J. A. & Olson, E. N., Jan 1 2002, In : Nature. 415, 6868, p. 168-171 4 p.

Research output: Contribution to journalLetter

429 Scopus citations

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

Matsuzaki, I., Sakurai, T., Kunii, K., Nakamura, T., Yanagisawa, M. & Goto, K., Mar 15 2002, In : Regulatory Peptides. 104, 1-3, p. 119-123 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Orexins: From neuropeptides to energy homeostasis and sleep/wake regulation

Beuckmann, C. T. & Yanagisawa, M., Jul 25 2002, In : Journal of Molecular Medicine. 80, 6, p. 329-342 14 p.

Research output: Contribution to journalReview article

117 Scopus citations

Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells

Oike, Y., Ito, Y., Hamada, K., Zhang, X. Q., Miyata, K., Arai, F., Inada, T., Araki, K., Nakagata, N., Takeya, M., Kisanuki, Y. Y., Yanagisawa, M., Gale, N. W. & Suda, T., Aug 15 2002, In : Blood. 100, 4, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: Molecular genetic evidence

Huang, H., Yanagisawa, M., Kisanuki, Y. Y., Jelicks, L. A., Chandra, M., Factor, S. M., Wittner, M., Weiss, L. M., Pestell, R. G., Shtutin, V., Shirani, J. & Tanowitz, H. B., Aug 1 2002, In : Clinical science. 103, SUPPL. 48, p. 263S-266S

Research output: Contribution to journalArticle

20 Scopus citations

Role of endothelin ETB receptors in the renal hemodynamic and excretory responses to big endothelin-1

Konishi, F., Okada, Y., Takaoka, M., Gariepy, C. E., Yanagisawa, M. & Matsumura, Y., Sep 13 2002, In : European Journal of Pharmacology. 451, 2, p. 177-184 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sleep, feeding, and neuropeptides: Roles of orexins and orexin receptors

Mieda, M. & Yanagisawa, M., Jun 1 2002, In : Current Opinion in Neurobiology. 12, 3, p. 339-345 7 p.

Research output: Contribution to journalReview article

84 Scopus citations

Vascular endothelin-B receptor system in vivo plays a favorable inhibitory role in vascular remodeling after injury revealed by endothelin-B receptor-knockout mice

Murakoshi, N., Miyauchi, T., Kakinuma, Y., Ohuchi, T., Goto, K., Yanagisawa, M. & Yamaguchi, I., Oct 8 2002, In : Circulation. 106, 15, p. 1991-1998 8 p.

Research output: Contribution to journalArticle

76 Scopus citations
2001

Differential expression of Orexin receptors 1 and 2 in the rat brain

Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M. & Elmquist, J. K., Jun 18 2001, In : Journal of Comparative Neurology. 435, 1, p. 6-25 20 p.

Research output: Contribution to journalArticle

1137 Scopus citations

Distinct cellular localization and regulation of endothelin-1 and endothelin-converting enzyme-1 expression in the bovine corpus luteum: Implications for luteolysis

Levy, N., Gordin, M., Mamluk, R., Yanagisawa, M., Smith, M. F., Hampton, J. H. & Meidan, R., Jan 1 2001, In : Endocrinology. 142, 12, p. 5254-5260 7 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis

Laghmani, K., Preisig, P. A., Moe, O. W., Yanagisawa, M. & Alpern, R. J., Jan 1 2001, In : Journal of Clinical Investigation. 107, 12, p. 1563-1569 7 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Endothelin-1 Stimulates Leptin Production in Adipocytes

Xiong, Y., Tanaka, H., Richardson, J. A., Williams, S. C., Slaughter, C. A., Nakamura, M., Chen, J. L. & Yanagisawa, M., Jul 27 2001, In : Journal of Biological Chemistry. 276, 30, p. 28471-28477 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction

Ivy, D. D., Mcmurtry, I. F., Yanagisawa, M., Gariepy, C. E., Le Cras, T. D., Gebb, S. A., Morris, K. G., Wiseman, R. C. & Abman, S. H., May 1 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 280, 5 25-5, p. L1040-L1048

Research output: Contribution to journalArticle

69 Scopus citations

Endothelin system: The double-edged sword in health and disease

Kedzierski, R. M. & Yanagisawa, M., May 10 2001, In : Annual Review of Pharmacology and Toxicology. 41, p. 851-876 26 p.

Research output: Contribution to journalReview article

565 Scopus citations

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis

Isermann, B., Hendrickson, S. B., Zogg, M., Wing, M., Cummiskey, M., Kisanuki, Y. Y., Yanagisawa, M. & Weiler, H., Sep 3 2001, In : Journal of Clinical Investigation. 108, 4, p. 537-546 10 p.

Research output: Contribution to journalArticle

100 Scopus citations

ETB receptor activation causes exocytic insertion of NHE3 in OKP cells

Peng, Y., Amemiya, M., Yang, X., Fan, L., Moe, O. W., Yin, H. L., Preisig, P. A., Yanagisawa, M. & Alpern, R. J., Jan 2001, In : American Journal of Physiology - Renal Physiology. 280, 1 49-1, p. F34-F42

Research output: Contribution to journalArticle

60 Scopus citations

Fos expression in orexin neurons varies with behavioral state

Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B. & Scammell, T. E., Mar 1 2001, In : Journal of Neuroscience. 21, 5, p. 1656-1662 7 p.

Research output: Contribution to journalArticle

517 Scopus citations

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K. I., Goto, K., Yanagisawa, M. & Sakurai, T., Jan 1 2001, In : Neuron. 30, 2, p. 345-354 10 p.

Research output: Contribution to journalArticle

1030 Scopus citations

Impaired ventilatory responses to hypoxia in mice deficient in endothelin-converting-enzyme-1

Renolleau, S., Dauger, S., Vardon, G., Levacher, B., Simonneau, M., Yanagisawa, M., Gaultier, C. & Gallego, J., Jan 1 2001, In : Pediatric Research. 49, 5, p. 705-712 8 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Orexin (hypocretin) neurons contain dynorphin.

Chou, T. C., Lee, C. E., Lu, J., Elmquist, J. K., Hara, J., Willie, J. T., Beuckmann, C. T., Chemelli, R. M., Sakurai, T., Yanagisawa, M., Saper, C. B. & Scammell, T. E., Oct 1 2001, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 21, 19, p. RC168

Research output: Contribution to journalArticle

306 Scopus citations

Role of D1x6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer

Charité, J., McFadden, D. G., Merlo, G., Levi, G., Clouthier, D. E., Yanagisawa, M., Richardson, J. A. & Olson, E. N., Nov 15 2001, In : Genes and Development. 15, 22, p. 3039-3049 11 p.

Research output: Contribution to journalArticle

98 Scopus citations

Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J. I., Williams, S. C., Richardson, J. A. & Yanagisawa, M., Feb 15 2001, In : Developmental Biology. 230, 2, p. 230-242 13 p.

Research output: Contribution to journalArticle

786 Scopus citations

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

Willie, J. T., Chemelli, R. M., Sinton, C. M. & Yanagisawa, M., Aug 11 2001, In : Annual Review of Neuroscience. 24, p. 429-458 30 p.

Research output: Contribution to journalReview article

607 Scopus citations
2000

Arterial pressure response to endothelin-1 and sarafotoxin 6c in rescued endothelin-B-deficient rats

Pollock, D. M., Portik-Dobos, V., Procter, C., Gariepy, C. E. & Yanagisawa, M., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S82-S85

Research output: Contribution to journalArticle

13 Scopus citations

Contribution of endogenous endothelin-1 and endothelin-A-receptors to the hypertensive state of endothelin-B heterozygous (+/-) knockout mice

Berthiaume, N., Yanagisawa, M. & D'Orleans-Juste, P., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S72-S74

Research output: Contribution to journalArticle

13 Scopus citations