• 71749 Citations
  • 119 h-Index
1984 …2019

Research output per year

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Research Output

1996

Expression of endothelin-1 in pancreatic tissue of patients with chronic pancreatitis

Kakugawa, Y., Giaid, A., Yanagisawa, M., Baynash, A. G., Melnyk, P., Rosenberg, L. & Duguid, W. P., Feb 9 1996, In : Journal of Pathology. 178, 1, p. 78-83 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Novel quinazoline endothelin converting enzyme inhibitors

Ahn, K., Sisneros, A. M., Pan, S., Hupe, D., Kam, S. N., Lee, C., Doherty, A., Kaw, S., Emoto, N. & Yanagisawa, M., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1404

Research output: Contribution to journalArticle

1 Scopus citations
171 Scopus citations

Rediscovering an endothelin antagonist (BQ-123): A self-deconvoluting cyclic pentapeptide library

Spatola, A. F., Crozet, Y., DeWit, D. & Yanagisawa, M., Sep 13 1996, In : Journal of Medicinal Chemistry. 39, 19, p. 3842-3846 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

Role of tyrosine kinase pathways in ET(B) receptor activation of NHE3

Chu, T. S., Tsuganezawa, H., Peng, Y., Cano, A., Yanagisawa, M. & Alpern, R. J., Sep 1 1996, In : American Journal of Physiology - Cell Physiology. 271, 3 40-3, p. C763-C771

Research output: Contribution to journalArticle

36 Scopus citations

Systemic hypertension induced by hepatic overexpression of human preproendothelin-1 in rats

Niranjan, V., Télémaque, S., De Wit, D., Gerard, R. D. & Yanagisawa, M., Nov 15 1996, In : Journal of Clinical Investigation. 98, 10, p. 2364-2372 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
1995

Analysis of C5a receptor by monoclonal antibody

Watanabe, H., Kuraya, M., Kasukawa, R., Yanagisawa, H., Yanagisawa, M. & Fujita, T., Sep 11 1995, In : Journal of Immunological Methods. 185, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat

Yoshimura, A., Iwasaki, S., Inui, K., Ideura, T., Koshikawa, S., Yanagisawa, M. & Masaki, T., Oct 1995, In : Kidney international. 48, 4, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Endothelin‐1 and Its Receptors in Human Testis

Maggi, M., Barni, T., Orlando, C., Fantoni, G., Finetti, G., Vannelli, G. B., Mancina, R., Gloria, L., Bonaccorsi, L., Yanagisawa, M. & Forti, G., Jan 1 1995, In : Journal of Andrology. 16, 3, p. 213-224 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Endothelin-1 immunoreactivity and mRNA in the transplanted human heart

Giaid, A., Saleh, D., Yanagisawa, M. & Forbes, R. D. C., May 15 1995, In : Transplantation. 59, 9, p. 1308-1313 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum

Emoto, N. & Yanagisawa, M., Jun 23 1995, In : Journal of Biological Chemistry. 270, 25, p. 15262-15268 7 p.

Research output: Contribution to journalArticle

Open Access
424 Scopus citations

Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia

Tonnessen, T., Giaid, A., Saleh, D., Naess, P. A., Yanagisawa, M. & Christensen, G., May 1995, In : Circulation research. 76, 5, p. 767-772 6 p.

Research output: Contribution to journalArticle

120 Scopus citations
1994

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

Puffenberger, E. G., Hosoda, K., Washington, S. S., Nakao, K., deWit, D., Yanagisawa, M. & Chakravarti, A., Dec 30 1994, In : Cell. 79, 7, p. 1257-1266 10 p.

Research output: Contribution to journalArticle

731 Scopus citations

Autoregulation of endothelin-1 secretion by cultured human keratinocytes via the endothelin B receptor

Yohn, J. J., Smith, C., Stevens, T., Morelli, J. G., Shurnas, L. R., Walchak, S. J., Hoffman, T. A., Kelley, K. K., Escobedo-Morse, A., Yanagisawa, M., Kane, M. A. & Zamora, M. R., Dec 30 1994, In : BBA - Molecular Cell Research. 1224, 3, p. 454-458 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D. & Yanagisawa, M., Aug 12 1994, In : Cell. 78, 3, p. 473-485 13 p.

Research output: Contribution to journalArticle

835 Scopus citations

Endotoxin and pro-inflammatory cytokines stimulate endothelin-1 expression and release by airway epithelial cells

Nakano, J., Takizawa, H., Ohtoshi, T., Shoji, S., Yamaguchi, M., Ishii, A., Yanagisawa, M. & Ito, K., Jun 27 1994, In : Clinical and Experimental Allergy. 24, 4, p. 330-336 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

Heparin suppresses endothelin-1 peptide and mRNA expression in cultured endothelial cells of spontaneously hypertensive rats

Yokokawa, K., Kohne, M., Mandal, A. K., Tahara, H., Yanagisawa, M. & Takeda, T., Mar 1 1994, In : Journal of the American Society of Nephrology. 4, 9, p. 1683-1689 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Human melanoma cells express functional endothelin-1 receptors

Yohn, J. J., Smith, C., Stevens, T., Hoffman, T. A., Morelli, J. G., Hurt, D. L., Yanagisawa, M., Kane, M. A. & Zamora, M. R., May 30 1994, In : Biochemical and Biophysical Research Communications. 201, 1, p. 449-457 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

Baynash, A. G., Hosoda, K., Giaid, A., Richardson, J. A., Emoto, N., Hammer, R. E. & Yanagisawa, M., Dec 30 1994, In : Cell. 79, 7, p. 1277-1285 9 p.

Research output: Contribution to journalArticle

767 Scopus citations

Phosphoinositide turnover signaling stimulated by ET-3 in endothelial cells from spontaneously hypertensive rats

Yokokawa, K., Johnson, J., Kohno, M., Mandal, A. K., Yanagisawa, M., Horio, T., Yasunari, K. & Takeda, T., 1994, In : AM.J.PHYSIOL.. 267, 3 part 2

Research output: Contribution to journalArticle

Phosphoinositide turnover signaling stimulated by ET-3 in endothelial cells from spontaneously hypertensive rats

Yokokawa, K., Johnson, J., Kohno, M., Mandal, A. K., Yanagisawa, M., Horio, T., Yasunari, K. & Takeda, T., Jan 1 1994, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 267, 3 36-3, p. R635-R644

Research output: Contribution to journalArticle

14 Scopus citations

Presence and distribution of endothelin-1 gene expression in human kidney

Pupilli, C., Brunori, M., Misciglia, N., Selli, C., Ianni, L., Yanagisawa, M., Mannelli, M. & Serio, M., 1994, In : AM.J.PHYSIOL.. 267, 4 part 2

Research output: Contribution to journalArticle

Presence and distribution of endothelin-1 gene expression in human kidney

Pupilli, C., Brunori, M., Misciglia, N., Selli, C., Ianni, L., Yanagisawa, M., Mannelli, M. & Serio, M., Jan 1 1994, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 267, 4 36-4, p. F679-F687

Research output: Contribution to journalArticle

51 Scopus citations

Pseudo-Noncompetitive Antagonism by BQ123 of Intracellular Calcium Transients Mediated by Human ETA Endothelin Receptor

Sakamoto, A., Yanagisawa, M., Tsujimoto, G., Nakao, K., Toyooka, T. & Masaki, T., Jan 1 1994, In : Biochemical and Biophysical Research Communications. 200, 2, p. 679-686 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

Hosoda, K., Hammer, R. E., Richardson, J. A., Baynash, A. G., Cheung, J. C., Giaid, A. & Yanagisawa, M., Dec 30 1994, In : Cell. 79, 7, p. 1267-1276 10 p.

Research output: Contribution to journalArticle

828 Scopus citations

The endothelin system: A new target for therapeutic intervention

Yanagisawa, M., Jan 1 1994, In : Circulation. 89, 3, p. 1320-1322 3 p.

Research output: Contribution to journalEditorial

Open Access
183 Scopus citations
1993

Arginine-vasopressin increases the release of ET-1 into perfusate of rat mesenteric artery

Tomobe, Y., Yanagisawa, M., Fujimori, A., Masaki, T. & Goto, K., Mar 15 1993, In : Biochemical and Biophysical Research Communications. 191, 2, p. 654-661 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane

Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. & Kimura, S., Feb 13 1993, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1161, 2-3, p. 295-302 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Distinct subdomains of human endothelin receptors determine their selectivity to endothelin(A)-selective antagonist and endothelin(B)-selective agonists

Sakamoto, A., Yanagisawa, M., Sawamura, T., Enoki, T., Ohtani, T., Sakurai, T., Nakao, K., Toyo-oka, T. & Masaki, T., Jan 1 1993, In : Journal of Biological Chemistry. 268, 12, p. 8547-8553 7 p.

Research output: Contribution to journalArticle

163 Scopus citations

Effect of endothelin receptor antagonist, BQ-123, on Ca2+ signaling in cultured rat mesangial cells

Yokokawa, K., Kohno, M., Johchi, M., Horio, T., Murakawa, K. I., Yasunari, K., Yanagisawa, M. & Takeda, T., 1993, In : Life Sciences. 53, 21, p. 1631-1641 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

Giaid, A., Yanagisawa, M., Langleben, D., Michel, R. P., Levy, R., Shennib, H., Kimura, S., Masaki, T., Duguid, W. P. & Stewart, D. J., Jun 17 1993, In : New England Journal of Medicine. 328, 24, p. 1732-1739 8 p.

Research output: Contribution to journalArticle

1534 Scopus citations

Heparin regulates endothelin production through endothelium-derived nitric oxide in human endothelial cells

Yokokawa, K., Tahara, H., Kohno, M., Mandal, A. K., Yanagisawa, M. & Takeda, T., Jan 1 1993, In : Journal of Clinical Investigation. 92, 4, p. 2080-2085 6 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations

Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12

Matsuoka, R., Yoshida, M. C., Furutani, Y., Imamura, S. I., Kanda, N., Yanagisawa, M., Masaki, T. & Takao, A., Jan 1 1993, In : American Journal of Medical Genetics. 46, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Intracellular localization of membrane-bound endothelin-converting enzyme from rat lung

Gui, G., Xu, D., Emoto, N. & Yanagisawa, M., Dec 1 1993, In : Journal of Cardiovascular Pharmacology. 22, SUPPL. 8, p. S53-S56

Research output: Contribution to journalArticle

23 Scopus citations

The ligand-receptor interactions of the endothelin systems are mediated by distinct 'message' and 'address' domains

Sakamoto, A., Yanagisawa, M., Sakurai, T., Nakao, K., Toyo-oka, T., Yano, M. & Masaki, T., Dec 1 1993, In : Journal of Cardiovascular Pharmacology. 22, SUPPL. 8, p. S113-S116

Research output: Contribution to journalArticle

13 Scopus citations
1992

Age- and sex-related variation of plasma endothelin-1 concentration in normal and hypertensive subjects

Miyauchi, T., Yanagisawa, M., Iida, K., Ajisaka, R., Suzuki, N., Fujino, M., Goto, K., Masaki, T. & Sugishita, Y., Apr 1992, In : American heart journal. 123, 4 PART 1, p. 1092-1093 2 p.

Research output: Contribution to journalArticle

117 Scopus citations

A pertussis toxin‐sensitive mechanism of endothelin action in porcine coronary artery smooth muscle

Kasuya, Y., Takuwa, Y., Yanagisawa, M., Masaki, T. & Goto, K., Oct 1992, In : British Journal of Pharmacology. 107, 2, p. 456-462 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Cardiovascular Effects of Endothelin

Goto, K., Yanagisawa, M., Kimura, S. & Masaki, T., Jan 1 1992, In : JAPANESE CIRCULATION JOURNAL. 56, 2, p. 162-169 8 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Complete primary structure and tissue expression of chicken pectoralis M- protein

Noguchi, J., Yanagisawa, M., Imamura, M., Kasuya, Y., Sakurai, T., Tanaka, T. & Masaki, T., Jan 1 1992, In : Journal of Biological Chemistry. 267, 28, p. 20302-20310 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Concomitant expression of receptor subtype and isopeptide of endothelin by human adrenal gland

Imai, T., Hirata, Y., Eguchi, S., Kanno, K., Ohta, K., Emori, T., Sakamoto, A., Yanagisawa, M., Masaki, T. & Marumo, F., Feb 14 1992, In : Biochemical and Biophysical Research Communications. 182, 3, p. 1115-1121 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Differential tissue expression of multiple genes for chicken smooth muscle/nonmuscle myosin regulatory light chains

Inoue, A., Yanagisawa, M. & Masaki, T., Mar 24 1992, In : BBA - Gene Structure and Expression. 1130, 2, p. 197-202 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Endothelin receptors in human parathyroid gland

Eguchi, S., Hirata, Y., Imai, T., Kanno, K., Akiba, T., Sakamoto, A., Yanagisawa, M., Masaki, T. & Marumo, F., May 15 1992, In : Biochemical and Biophysical Research Communications. 184, 3, p. 1448-1455 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Endothelins.

Masaki, T. & Yanagisawa, M., 1992, In : Essays in biochemistry. 27, p. 79-89 11 p.

Research output: Contribution to journalReview article

32 Scopus citations

Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension

Stelzner, T. J., O'Brien, R. F., Yanagisawa, M., Sakurai, T., Sato, K., Webb, S., Zamora, M., McMurtry, I. F. & Fisher, J. H., Jan 1 1992, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 262, 5 6-5, p. L614-L620

Research output: Contribution to journalArticle

149 Scopus citations

Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells

Imai, T., Hirata, Y., Emori, T., Yanagisawa, M., Masaki, T. & Marumo, F., Jun 1992, In : Hypertension. 19, 6, p. 753-757 5 p.

Research output: Contribution to journalArticle

Open Access
328 Scopus citations

Interleukin-2 Suppresses Endothelin-1 Secretion of Cultured Endothelial Cells

Taniguchi, K., Morimoto, S., Fukuo, K., Ogihara, T., Yanagisawa, M., Masaki, T. & Suzuki, N., 1992, In : Hypertension Research. 15, p. 171-175 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular characterization of endothelin receptors

Takeshi, S., Yanagisawa, M. & Tomoh, M., 1992, In : Trends in Pharmacological Sciences. 13, C, p. 103-108 6 p.

Research output: Contribution to journalReview article

594 Scopus citations

Physiology and pharmacology of endothelins

Masaki, T., Yanagisawa, M. & Goto, K., Jul 1992, In : Medicinal Research Reviews. 12, 4, p. 391-421 31 p.

Research output: Contribution to journalArticle

247 Scopus citations
1991

cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA

Sakurai, T., Yanagisawa, M., Inoue, A., Ryan, U. S., Kimura, S., Mitsui, Y., Goto, K. & Masaki, T., Feb 28 1991, In : Biochemical and Biophysical Research Communications. 175, 1, p. 44-47 4 p.

Research output: Contribution to journalArticle

232 Scopus citations

Characteristics of binding of endothelin-1 and endothelin-3 to rat hearts: Developmental changes in mechanical responses and receptor subtypes

Ishikawa, T., Li, L., Shinmi, O., Kimura, S., Yanagisawa, M., Goto, K. & Masaki, T., Jan 1 1991, In : Circulation research. 69, 4, p. 918-926 9 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations