• 72581 Citations
  • 120 h-Index
1984 …2020

Research output per year

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Research Output

2001

Impaired ventilatory responses to hypoxia in mice deficient in endothelin-converting-enzyme-1

Renolleau, S., Dauger, S., Vardon, G., Levacher, B., Simonneau, M., Yanagisawa, M., Gaultier, C. & Gallego, J., 2001, In : Pediatric Research. 49, 5, p. 705-712 8 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Orexin (hypocretin) neurons contain dynorphin.

Chou, T. C., Lee, C. E., Lu, J., Elmquist, J. K., Hara, J., Willie, J. T., Beuckmann, C. T., Chemelli, R. M., Sakurai, T., Yanagisawa, M., Saper, C. B. & Scammell, T. E., Oct 1 2001, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 21, 19, p. RC168

Research output: Contribution to journalArticle

Open Access
310 Scopus citations

Role of D1x6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer

Charité, J., McFadden, D. G., Merlo, G., Levi, G., Clouthier, D. E., Yanagisawa, M., Richardson, J. A. & Olson, E. N., Nov 15 2001, In : Genes and Development. 15, 22, p. 3039-3049 11 p.

Research output: Contribution to journalArticle

100 Scopus citations

Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J. I., Williams, S. C., Richardson, J. A. & Yanagisawa, M., Feb 15 2001, In : Developmental Biology. 230, 2, p. 230-242 13 p.

Research output: Contribution to journalArticle

797 Scopus citations

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

Willie, J. T., Chemelli, R. M., Sinton, C. M. & Yanagisawa, M., Aug 11 2001, In : Annual Review of Neuroscience. 24, p. 429-458 30 p.

Research output: Contribution to journalReview article

612 Scopus citations
2000

Arterial pressure response to endothelin-1 and sarafotoxin 6c in rescued endothelin-B-deficient rats

Pollock, D. M., Portik-Dobos, V., Procter, C., Gariepy, C. E. & Yanagisawa, M., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S82-S85

Research output: Contribution to journalArticle

13 Scopus citations

Contribution of endogenous endothelin-1 and endothelin-A-receptors to the hypertensive state of endothelin-B heterozygous (+/-) knockout mice

Berthiaume, N., Yanagisawa, M. & D'Orleans-Juste, P., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S72-S74

Research output: Contribution to journalArticle

13 Scopus citations

Deletion of the endothelin-A-receptor suppresses oxygen-induced constriction but not postnatal closure of the ductus arteriosus

Coceani, F., Liu, Y. A., Seidlitz, E., Kelsey, L., Kuwaki, T., Ackerley, C. & Yanagisawa, M., Nov 16 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S75-S77

Research output: Contribution to journalArticle

11 Scopus citations

Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Emoto, N., Clay Williams, S., Takeda, S. I., Clouthier, D. E. & Yanagisawa, M., May 2000, In : Journal of Clinical Investigation. 105, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

Open Access
163 Scopus citations

Enhanced blood pressure sensitivity to DOCA-salt treatment in endothelin ET(B) receptor-deficient rats

Matsumura, Y., Kuro, T., Konishi, F., Takaoka, M., Gariepy, C. E. & Yanagisawa, M., Jan 1 2000, In : British Journal of Pharmacology. 129, 6, p. 1060-1062 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension

Matsumura, Y., Kuro, T., Kobayashi, Y., Konishi, F., Takaoka, M., Wessale, J. L., Opgenorth, T. J., Gariepy, C. E. & Yanagisawa, M., Nov 28 2000, In : Circulation. 102, 22, p. 2765-2773 9 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Functional analysis of five endothelin-B receptor mutations found in human hirschsprung disease patients

Abe, Y., Sakurai, T., Yamada, T., Nakamura, T., Yanagisawa, M. & Goto, K., Aug 28 2000, In : Biochemical and Biophysical Research Communications. 275, 2, p. 524-531 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Heterozygous knock-out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse

Berthiaume, N., Yanagisawa, M., Labonté, J. & D'Orléans-Juste, P., Jan 1 2000, In : Hypertension. 36, 6, p. 1002-1007 6 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

Hypothalamic arousal regions are activated during modafinil-induced wakefulness

Scammell, T. E., Estabrooke, I. V., McCarthy, M. T., Chemelli, R. M., Yanagisawa, M., Miller, M. S. & Saper, C. B., Nov 15 2000, In : Journal of Neuroscience. 20, 22, p. 8620-8628 9 p.

Research output: Contribution to journalArticle

Open Access
417 Scopus citations

Increased susceptibility to deoxycorticosterone acetate-salt-induced hypertension in endothelin-B-receptor-deficient rats

Matsumura, Y., Kuro, T., Kobayashi, Y., Konishi, F., Takaoka, M., Wessale, J. L., Opgenorth, T. J., Gariepy, C. E. & Yanagisawa, M., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S86-S89

Research output: Contribution to journalArticle

5 Scopus citations

Normal ventilation and ventilatory responses to chemical stimuli in juvenile mutant mice deficient in endothelin-3

Nakamura, A., Kuwaki, T., Kuriyama, T., Yanagisawa, M. & Fukuda, Y., Nov 27 2000, In : Respiration Physiology. 124, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Nakamura, T., Uramura, K., Nambu, T., Yada, T., Goto, K., Yanagisawa, M. & Sakurai, T., Aug 4 2000, In : Brain Research. 873, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

289 Scopus citations

Renal tubular effects of endothelin-B receptor signaling: Its role in cardiovascular homeostasis and extracellular volume regulation

Ohuchi, T., Yanagisawa, M. & Gariepy, C. E., Jul 24 2000, In : Current opinion in nephrology and hypertension. 9, 4, p. 435-439 5 p.

Research output: Contribution to journalReview article

27 Scopus citations

Salt-sensitive hypertension in endothelin-B receptor-deficient rats

Gariepy, C. E., Ohuchi, T., Williams, S. C., Richardson, J. A. & Yanagisawa, M., Apr 2000, In : Journal of Clinical Investigation. 105, 7, p. 925-933 9 p.

Research output: Contribution to journalArticle

Open Access
247 Scopus citations

Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin

Kane, J. K., Tanaka, H., Parker, S. L., Yanagisawa, M. & Li, M. D., Jun 16 2000, In : Biochemical and Biophysical Research Communications. 272, 3, p. 959-965 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice

Clouthier, D. E., Williams, S. C., Yanagisawa, H., Wieduwilt, M., Richardson, J. A. & Yanagisawa, M., Jan 1 2000, In : Developmental Biology. 217, 1, p. 10-24 15 p.

Research output: Contribution to journalArticle

160 Scopus citations

Tissue-specific modulation of endothelin receptors in a rat model of hypertension

Telemaque-Potts, S., Kuc, R. E., Yanagisawa, M. & Davenport, A. P., Jan 1 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1, p. S122-S123

Research output: Contribution to journalArticle

5 Scopus citations

Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice

Rice, J., Doggett, B., Sweetser, D. A., Yanagisawa, H., Yanagisawa, M. & Kapur, R. P., Jan 19 2000, In : Developmental Dynamics. 217, 1, p. 120-132 13 p.

Research output: Contribution to journalArticle

34 Scopus citations
1999

Constitutive lysosomal targeting and degradation of bovine endothelin- converting enzyme-1a mediated by novel signals in its alternatively spliced cytoplasmic tail

Emoto, N., Nurhantari, Y., Alimsardjono, H., Xie, J., Yamada, T., Yanagisawa, M. & Matsuo, M., Jan 15 1999, In : Journal of Biological Chemistry. 274, 3, p. 1509-1518 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Cyclic expression of endothelin-converting enzyme-1 mediates the functional regulation of seminiferous tubule contraction

Tripiciano, A., Peluso, C., Morena, A. R., Palombi, F., Stefanini, M., Ziparo, E., Yanagisawa, M. & Filippini, A., May 31 1999, In : Journal of Cell Biology. 145, 5, p. 1027-1038 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Distribution of orexin neurons in the adult rat brain

Nambu, T., Sakurai, T., Mizukami, K., Hosoya, Y., Yanagisawa, M. & Goto, K., May 8 1999, In : Brain Research. 827, 1-2, p. 243-260 18 p.

Research output: Contribution to journalArticle

869 Scopus citations

Elevation of blood pressure by genetic and pharmacological disruption of the ET(B) receptor in mice

Ohuchi, T., Kuwaki, T., Ling, G. Y., Dewit, D., Ju, K. H., Onodera, M., Cao, W. H., Yanagisawa, M. & Kumada, M., Apr 1 1999, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 276, 4 45-4, p. R1071-R1077

Research output: Contribution to journalArticle

94 Scopus citations

Endothelin A receptor is necessary for O2 constriction but not closure of ductus arteriosus

Coceani, F., Liu, Y. A., Seidlitz, E., Kelsey, L., Kuwaki, T., Ackerley, C. & Yanagisawa, M., Oct 1999, In : American Journal of Physiology - Heart and Circulatory Physiology. 277, 4 46-4, p. H1521-H1531

Research output: Contribution to journalArticle

55 Scopus citations

Endothelin in the central control of cardiovascular and respiratory functions

Kuwaki, T., Ling, G. Y., Onodera, M., Ishii, T., Nakamura, A., Ju, K. H., Cao, W. H., Kumada, M., Kurihara, H., Kurihara, Y., Yazaki, Y., Ohuchi, T., Yanagisawa, M. & Fukuda, Y., Dec 1 1999, In : Clinical and Experimental Pharmacology and Physiology. 26, 12, p. 989-994 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

ET(B) receptor activation leads to activation and phosphorylation of NHE3

Peng, Y., Moe, O. W., Chu, T. S., Preisig, P. A., Yanagisawa, M. & Alpern, R. J., Jan 1 1999, In : American Journal of Physiology - Cell Physiology. 276, 4 45-4, p. C938-C945

Research output: Contribution to journalArticle

36 Scopus citations

Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus

Håkansson, M. L., De Lecea, L., Sutcliffe, J. G., Yanagisawa, M. & Meister, B., Jul 29 1999, In : Journal of Neuroendocrinology. 11, 8, p. 653-663 11 p.

Research output: Contribution to journalArticle

205 Scopus citations

Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Clay Williams, S., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M., Aug 20 1999, In : Cell. 98, 4, p. 437-451 15 p.

Research output: Contribution to journalArticle

2372 Scopus citations

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

Moriguchi, T., Sakurai, T., Nambu, T., Yanagisawa, M. & Goto, K., Apr 2 1999, In : Neuroscience Letters. 264, 1-3, p. 101-104 4 p.

Research output: Contribution to journalArticle

237 Scopus citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M. & Nakazato, M., Jan 19 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 2, p. 748-753 6 p.

Research output: Contribution to journalArticle

884 Scopus citations

Structure and function of human prepro-orexin gene

Sakurai, T., Moriguchi, T., Furuya, K., Kajiwara, N., Nakamura, T., Yanagisawa, M. & Goto, K., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17771-17776 6 p.

Research output: Contribution to journalArticle

165 Scopus citations

Widespread distribution of orexin in rat brain and its regulation upon fasting

Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Yanagisawa, M. & Matsukura, S., Mar 24 1999, In : Biochemical and Biophysical Research Communications. 256, 3, p. 495-499 5 p.

Research output: Contribution to journalArticle

129 Scopus citations
1998

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

Elias, C. F., Saper, C. B., Maratos-Flier, E., Tritos, N. A., Lee, C., Kelly, J., Tatro, J. B., Huffman, G. E., Ollmann, M. M., Barsh, G. S., Sakurai, T., Yanagisawa, M. & Elmquist, J. K., Dec 28 1998, In : Journal of Comparative Neurology. 402, 4, p. 442-459 18 p.

Research output: Contribution to journalArticle

726 Scopus citations

Cloning and characterization of a novel endothelin receptor subtype in the avian class

Lecoin, L., Sakurai, T., Ngo, M. T., Abe, Y., Yanagisawa, M. & Le Douarin, N. M., Mar 17 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 6, p. 3024-3029 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

Yanagisawa, H., Yanagisawa, M., Kapur, R. P., Richardson, J. A., Williams, S. C., Clouthier, D. E., De Wit, D., Emoto, N. & Hammer, R. E., Apr 11 1998, In : Development. 125, 5, p. 825-836 12 p.

Research output: Contribution to journalArticle

410 Scopus citations

Efficacy of administering an endothelin-receptor antagonist (SB209670) in ameliorating ischemia-reperfusion injury in lung allografts

Shennib, H., Lee, A. G. L., Kuang, J. Q., Yanagisawa, M., Ohlstein, E. H. & Giaid, A., Jan 1 1998, In : American journal of respiratory and critical care medicine. 157, 6 PART I, p. 1975-1981 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endothelin: New discoveries and rapid progress in the clinic

Webb, D. J., Monge, J. C., Rabelink, T. J. & Yanagisawa, M., Jan 1 1998, In : Trends in Pharmacological Sciences. 19, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

131 Scopus citations

Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells

Takizawa, H., Desaki, M., Ohtoshi, T., Kawasaki, S., Kohyama, T., Sato, M., Nakajima, J., Yanagisawa, M. & Ito, K., Jul 1 1998, In : European Respiratory Journal. 12, 1, p. 57-63 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats

Télémaque, S., Emoto, N., DeWit, D. & Yanagisawa, M., Jan 1 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S548-S550

Research output: Contribution to journalArticle

18 Scopus citations

Novel mutations of the endothelin B receptor gene in patients with Hirschsprung's disease and their characterization

Tanaka, H., Moroi, K., Iwai, J., Takahashi, H., Ohnuma, N., Hori, S., Takimoto, M., Nishiyama, M., Masaki, T., Yanagisawa, M., Sekiya, S. & Kimura, S., May 1 1998, In : Journal of Biological Chemistry. 273, 18, p. 11378-11383 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Novel selective quinazoline inhibitors of endothelin converting enzyme-1

Ahn, K., Sisneros, A. M., Herman, S. B., Pan, S. M., Hupe, D., Lee, C., Nikam, S., Cheng, X. M., Doherty, A. M., Schroeder, R. L., Haleen, S. J., Kaw, S., Emoto, N. & Yanagisawa, M., Feb 4 1998, In : Biochemical and Biophysical Research Communications. 243, 1, p. 184-190 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W. S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & 1 others, Yanagisawa, M., Feb 20 1998, In : Cell. 92, 4, p. 573-585 13 p.

Research output: Contribution to journalArticle

2656 Scopus citations

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richarson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W. S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & 1 others, Yanagisawa, M., Mar 6 1998, In : Cell. 92, 5, p. 1 page following 696

Research output: Contribution to journalComment/debate

1456 Scopus citations

Pharmacology of endothelins in vascular circuits of normal or heterozygous endothelin-A or endothelin-B knockout transgenic mice

Berthiaume, N., Yanagisawa, M., Yanagisawa, H., DeWit, D. & D'Orléans-Juste, P., Jan 1 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S561-S564

Research output: Contribution to journalArticle

13 Scopus citations

Pulmonary disease models induced by in vivo hemagglutinating virus of Japan liposome-mediated endothelin-1 gene transfer

Takeda, S. I., Miyoshi, S., Omori, K. I., Utsumi, T., Kogaki, S., Sawa, Y., Yanagisawa, M. & Matsuda, H., Jan 1 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S336-S338

Research output: Contribution to journalArticle

4 Scopus citations

Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Williams, S. C., Clouthier, D. E. & Yanagisawa, M., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

Open Access
164 Scopus citations