• 71419 Citations
  • 119 h-Index
1984 …2019

Research output per year

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Research Output

  • 71419 Citations
  • 119 h-Index
  • 451 Article
  • 3 Chapter
  • 3 Conference contribution
2000

Increased susceptibility to deoxycorticosterone acetate-salt-induced hypertension in endothelin-B-receptor-deficient rats

Matsumura, Y., Kuro, T., Kobayashi, Y., Konishi, F., Takaoka, M., Wessale, J. L., Opgenorth, T. J., Gariepy, C. E. & Yanagisawa, M., 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1

Research output: Contribution to journalArticle

5 Scopus citations

Normal ventilation and ventilatory responses to chemical stimuli in juvenile mutant mice deficient in endothelin-3

Nakamura, A., Kuwaki, T., Kuriyama, T., Yanagisawa, M. & Fukuda, Y., 2000, In : Respiration Physiology. 124, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Nakamura, T., Uramura, K., Nambu, T., Yada, T., Goto, K., Yanagisawa, M. & Sakurai, T., Aug 4 2000, In : Brain Research. 873, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

283 Scopus citations
26 Scopus citations

Salt-sensitive hypertension in endothelin-B receptor-deficient rats

Gariepy, C. E., Ohuchi, T., Williams, S. C., Richardson, J. A. & Yanagisawa, M., Apr 2000, In : Journal of Clinical Investigation. 105, 7, p. 925-933 9 p.

Research output: Contribution to journalArticle

244 Scopus citations

Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin

Kane, J. K., Tanaka, H., Parker, S. L., Yanagisawa, M. & Li, M. D., Jun 16 2000, In : Biochemical and Biophysical Research Communications. 272, 3, p. 959-965 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice

Clouthier, D. E., Williams, S. C., Yanagisawa, H., Wieduwilt, M., Richardson, J. A. & Yanagisawa, M., Jan 1 2000, In : Developmental Biology. 217, 1, p. 10-24 15 p.

Research output: Contribution to journalArticle

156 Scopus citations

Tissue-specific modulation of endothelin receptors in a rat model of hypertension

Telemaque-Potts, S., Kuc, R. E., Yanagisawa, M. & Davenport, A. P., 2000, In : Journal of Cardiovascular Pharmacology. 36, 5 SUPPL. 1

Research output: Contribution to journalArticle

5 Scopus citations

Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice

Rice, J., Doggett, B., Sweetser, D. A., Yanagisawa, H., Yanagisawa, M. & Kapur, R. P., 2000, In : Developmental Dynamics. 217, 1, p. 120-132 13 p.

Research output: Contribution to journalArticle

34 Scopus citations
1999

Constitutive lysosomal targeting and degradation of bovine endothelin- converting enzyme-1a mediated by novel signals in its alternatively spliced cytoplasmic tail

Emoto, N., Nurhantari, Y., Alimsardjono, H., Xie, J., Yamada, T., Yanagisawa, M. & Matsuo, M., Jan 15 1999, In : Journal of Biological Chemistry. 274, 3, p. 1509-1518 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Cyclic expression of endothelin-converting enzyme-1 mediates the functional regulation of seminiferous tubule contraction

Tripiciano, A., Peluso, C., Morena, A. R., Palombi, F., Stefanini, M., Ziparo, E., Yanagisawa, M. & Filippini, A., May 31 1999, In : Journal of Cell Biology. 145, 5, p. 1027-1038 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Distribution of orexin neurons in the adult rat brain

Nambu, T., Sakurai, T., Mizukami, K., Hosoya, Y., Yanagisawa, M. & Goto, K., May 8 1999, In : Brain Research. 827, 1-2, p. 243-260 18 p.

Research output: Contribution to journalArticle

853 Scopus citations

Elevation of blood pressure by genetic and pharmacological disruption of the ET(B) receptor in mice

Ohuchi, T., Kuwaki, T., Ling, G. Y., Dewit, D., Ju, K. H., Onodera, M., Cao, W. H., Yanagisawa, M. & Kumada, M., Apr 1999, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 276, 4 45-4

Research output: Contribution to journalArticle

94 Scopus citations

Endothelin A receptor is necessary for O2 constriction but not closure of ductus arteriosus

Coceani, F., Liu, Y. A., Seidlitz, E., Kelsey, L., Kuwaki, T., Ackerley, C. & Yanagisawa, M., Oct 1999, In : American Journal of Physiology - Heart and Circulatory Physiology. 277, 4 46-4

Research output: Contribution to journalArticle

54 Scopus citations

Endothelin in the central control of cardiovascular and respiratory functions

Kuwaki, T., Ling, G. Y., Onodera, M., Ishii, T., Nakamura, A., Ju, K. H., Cao, W. H., Kumada, M., Kurihara, H., Kurihara, Y., Yazaki, Y., Ohuchi, T., Yanagisawa, M. & Fukuda, Y., 1999, In : Clinical and Experimental Pharmacology and Physiology. 26, 12, p. 989-994 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

ET(B) receptor activation leads to activation and phosphorylation of NHE3

Peng, Y., Moe, O. W., Chu, T. S., Preisig, P. A., Yanagisawa, M. & Alpern, R. J., 1999, In : American Journal of Physiology - Cell Physiology. 276, 4 45-4

Research output: Contribution to journalArticle

36 Scopus citations

Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus

Håkansson, M. L., De Lecea, L., Sutcliffe, J. G., Yanagisawa, M. & Meister, B., 1999, In : Journal of Neuroendocrinology. 11, 8, p. 653-663 11 p.

Research output: Contribution to journalArticle

204 Scopus citations

Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Clay Williams, S., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M., Aug 20 1999, In : Cell. 98, 4, p. 437-451 15 p.

Research output: Contribution to journalArticle

2333 Scopus citations

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

Moriguchi, T., Sakurai, T., Nambu, T., Yanagisawa, M. & Goto, K., Apr 2 1999, In : Neuroscience Letters. 264, 1-3, p. 101-104 4 p.

Research output: Contribution to journalArticle

236 Scopus citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M. & Nakazato, M., Jan 19 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 2, p. 748-753 6 p.

Research output: Contribution to journalArticle

870 Scopus citations

Structure and function of human prepro-orexin gene

Sakurai, T., Moriguchi, T., Furuya, K., Kajiwara, N., Nakamura, T., Yanagisawa, M. & Goto, K., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17771-17776 6 p.

Research output: Contribution to journalArticle

160 Scopus citations

Widespread distribution of orexin in rat brain and its regulation upon fasting

Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Yanagisawa, M. & Matsukura, S., Mar 24 1999, In : Biochemical and Biophysical Research Communications. 256, 3, p. 495-499 5 p.

Research output: Contribution to journalArticle

128 Scopus citations
1998

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

Elias, C. F., Saper, C. B., Maratos-Flier, E., Tritos, N. A., Lee, C., Kelly, J., Tatro, J. B., Huffman, G. E., Ollmann, M. M., Barsh, G. S., Sakurai, T., Yanagisawa, M. & Elmquist, J. K., Dec 28 1998, In : Journal of Comparative Neurology. 402, 4, p. 442-459 18 p.

Research output: Contribution to journalArticle

719 Scopus citations

Cloning and characterization of a novel endothelin receptor subtype in the avian class

Lecoin, L., Sakurai, T., Ngo, M. T., Abe, Y., Yanagisawa, M. & Le Douarin, N. M., Mar 17 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 6, p. 3024-3029 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

Yanagisawa, H., Yanagisawa, M., Kapur, R. P., Richardson, J. A., Williams, S. C., Clouthier, D. E., De Wit, D., Emoto, N. & Hammer, R. E., 1998, In : Development. 125, 5, p. 825-836 12 p.

Research output: Contribution to journalArticle

405 Scopus citations

Efficacy of administering an endothelin-receptor antagonist (SB209670) in ameliorating ischemia-reperfusion injury in lung allografts

Shennib, H., Lee, A. G. L., Kuang, J. Q., Yanagisawa, M., Ohlstein, E. H. & Giaid, A., 1998, In : American Journal of Respiratory and Critical Care Medicine. 157, 6 I, p. 1975-1981 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endothelin: New discoveries and rapid progress in the clinic

Webb, D. J., Monge, J. C., Rabelink, T. J. & Yanagisawa, M., Jan 1 1998, In : Trends in Pharmacological Sciences. 19, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

131 Scopus citations

Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells

Takizawa, H., Desaki, M., Ohtoshi, T., Kawasaki, S., Kohyama, T., Sato, M., Nakajima, J., Yanagisawa, M. & Ito, K., Jul 1998, In : European Respiratory Journal. 12, 1, p. 57-63 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats

Télémaque, S., Emoto, N., DeWit, D. & Yanagisawa, M., 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1

Research output: Contribution to journalArticle

18 Scopus citations

Novel mutations of the endothelin B receptor gene in patients with Hirschsprung's disease and their characterization

Tanaka, H., Moroi, K., Iwai, J., Takahashi, H., Ohnuma, N., Hori, S., Takimoto, M., Nishiyama, M., Masaki, T., Yanagisawa, M., Sekiya, S. & Kimura, S., May 1 1998, In : Journal of Biological Chemistry. 273, 18, p. 11378-11383 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Novel selective quinazoline inhibitors of endothelin converting enzyme-1

Ahn, K., Sisneros, A. M., Herman, S. B., Pan, S. M., Hupe, D., Lee, C., Nikam, S., Cheng, X. M., Doherty, A. M., Schroeder, R. L., Haleen, S. J., Kaw, S., Emoto, N. & Yanagisawa, M., Feb 4 1998, In : Biochemical and Biophysical Research Communications. 243, 1, p. 184-190 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W. S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & 1 others, Yanagisawa, M., Feb 20 1998, In : Cell. 92, 4, p. 573-585 13 p.

Research output: Contribution to journalArticle

2575 Scopus citations

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richarson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W. S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & 1 others, Yanagisawa, M., Mar 6 1998, In : Cell. 92, 5

Research output: Contribution to journalArticle

1459 Scopus citations

Pharmacology of endothelins in vascular circuits of normal or heterozygous endothelin-A or endothelin-B knockout transgenic mice

Berthiaume, N., Yanagisawa, M., Yanagisawa, H., DeWit, D. & D'Orléans-Juste, P., 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1

Research output: Contribution to journalArticle

14 Scopus citations

Pulmonary disease models induced by in vivo hemagglutinating virus of Japan liposome-mediated endothelin-1 gene transfer

Takeda, S. I., Miyoshi, S., Omori, K. I., Utsumi, T., Kogaki, S., Sawa, Y., Yanagisawa, M. & Matsuda, H., 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1

Research output: Contribution to journalArticle

4 Scopus citations

Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Williams, S. C., Clouthier, D. E. & Yanagisawa, M., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

163 Scopus citations

The expression pattern of endothelin 3 in the avian embryo

Nataf, V., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., May 1998, In : Mechanisms of Development. 73, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo

Nataf, V., Grapin-Botton, A., Champeval, D., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., Jul 1998, In : Mechanisms of Development. 75, 1-2, p. 145-149 5 p.

Research output: Contribution to journalArticle

30 Scopus citations
145 Scopus citations
1997

Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse

Mizuguchi, T., Nishiyama, M., Moroi, K., Tanaka, H., Saito, T., Masuda, Y., Masaki, T., De Wit, D., Yanagisawa, M. & Kimura, S., 1997, In : British Journal of Pharmacology. 120, 8, p. 1427-1430 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

Elevated Expression of Endothelin-1 and Endothelin-converting Enzyme-1 in Idiopathic Pulmonary Fibrosis: Possible Involvement of Proinflammatory Cytokines

Saleh, D., Furukawa, K., Tsao, M. S., Maghazachi, A., Corrin, B., Yanagisawa, M., Barnes, P. J. & Giaid, A., 1997, In : American Journal of Respiratory Cell and Molecular Biology. 16, 2, p. 187-193 7 p.

Research output: Contribution to journalArticle

141 Scopus citations

Endothelin and its signaling - Genetic analysis in mice

Yanagisawa, M., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Experimental bronchiolitis obliterans induced by in vivo HVJ-liposome- mediated endothelin-1 gene transfer

Takeda, S. I., Sawa, Y., Minami, M., Kaneda, Y., Fujii, Y., Shirakura, R., Yanagisawa, M. & Matsuda, H., Jun 1997, In : Annals of Thoracic Surgery. 63, 6, p. 1562-1567 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Gene therapy for Hirschsprung disease?

Kapur, R. P., Yanagisawa, M., Yanagisawa, H. & Rice, J., 1997, In : Pediatric Pathology and Laboratory Medicine. 17, 3, p. 516-517 2 p.

Research output: Contribution to journalArticle

Localization of endothelin-converting enzyme-1 in human kidney

Pupilli, C., Romagnani, P., Lasagni, L., Bellini, F., Misciglia, N., Emoto, N., Yanagisawa, M., Rizzo, M., Mannelli, M. & Serio, M., 1997, In : American Journal of Physiology - Renal Physiology. 273, 5 42-5

Research output: Contribution to journalArticle

25 Scopus citations

Studies on endothelium-dependent vasorelaxation by hydralazine in porcine coronary artery

Wei, S., Kasuya, Y., Yanagisawa, M., Kimura, S., Masaki, T. & Goto, K., Mar 5 1997, In : European Journal of Pharmacology. 321, 3, p. 307-314 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
1996

Co-expression of Endothelin-1 and Endothelin-Converting Enzyme-1 in Patients with Chronic Rhinitis

Furukawa, K., Saleh, D., Bayan, F., Emoto, N., Kaw, S., Yanagisawa, M. & Giaid, A., 1996, In : American Journal of Respiratory Cell and Molecular Biology. 14, 3, p. 248-253 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Endothelin-3 frameshift mutation in congenital central hypoventilation syndrome

Bolk, S., Angrist, M., Xie, J., Yanagisawa, M., Silvestri, J. M., Weese-Mayer, D. E. & Chakravarti, A., 1996, In : Nature Genetics. 13, 4, p. 395-396 2 p.

Research output: Contribution to journalArticle

79 Scopus citations

EndothelinB receptor activates NHE-3 by a Ca2+ -dependent pathway in OKP cells

Chu, T. S., Peng, Y., Cano, A., Yanagisawa, M. & Alpern, R. J., Mar 15 1996, In : Journal of Clinical Investigation. 97, 6, p. 1454-1462 9 p.

Research output: Contribution to journalArticle

65 Scopus citations