• 71926 Citations
  • 119 h-Index
1984 …2020

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Differential expression of Orexin receptors 1 and 2 in the rat brain

Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M. & Elmquist, J. K., Jun 18 2001, In : Journal of Comparative Neurology. 435, 1, p. 6-25 20 p.

Research output: Contribution to journalArticle

1137 Scopus citations

Differential Roles of Each Orexin Receptor Signaling in Obesity

Kakizaki, M., Tsuneoka, Y., Takase, K., Kim, S. J., Choi, J., Ikkyu, A., Abe, M., Sakimura, K., Yanagisawa, M. & Funato, H., Oct 25 2019, In : iScience. 20, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Differential roles of orexin receptor-1 and -2 in the regulation of Non-REM and REM sleep

Mieda, M., Hasegawa, E., Kisanuki, Y. Y., Sinton, C. M., Yanagisawa, M. & Sakurai, T., Apr 27 2011, In : Journal of Neuroscience. 31, 17, p. 6518-6526 9 p.

Research output: Contribution to journalArticle

145 Scopus citations

Differential tissue expression of multiple genes for chicken smooth muscle/nonmuscle myosin regulatory light chains

Inoue, A., Yanagisawa, M. & Masaki, T., Mar 24 1992, In : BBA - Gene Structure and Expression. 1130, 2, p. 197-202 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis

Lenoir, O., Milon, M., Virsolvy, A., Hénique, C., Schmitt, A., Massé, J. M., Kotelevtsev, Y., Yanagisawa, M., Webb, D. J., Richard, S. & Tharaux, P. L., May 1 2014, In : Journal of the American Society of Nephrology. 25, 5, p. 1050-1062 13 p.

Research output: Contribution to journalArticle

49 Scopus citations

Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine

Narita, M., Nagumo, Y., Hashimoto, S., Narita, M., Khotib, J., Miyatake, M., Sakurai, T., Yanagisawa, M., Nakamachi, T., Shioda, S. & Suzuki, T., Jan 11 2006, In : Journal of Neuroscience. 26, 2, p. 398-405 8 p.

Research output: Contribution to journalArticle

384 Scopus citations

Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Emoto, N., Clay Williams, S., Takeda, S. I., Clouthier, D. E. & Yanagisawa, M., May 2000, In : Journal of Clinical Investigation. 105, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

Open Access
163 Scopus citations

Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion

Stösser, S., Agarwal, N., Tappe-Theodor, A., Yanagisawa, M. & Kuner, R., Feb 1 2010, In : Pain. 148, 2, p. 206-214 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Distinct cellular localization and regulation of endothelin-1 and endothelin-converting enzyme-1 expression in the bovine corpus luteum: Implications for luteolysis

Levy, N., Gordin, M., Mamluk, R., Yanagisawa, M., Smith, M. F., Hampton, J. H. & Meidan, R., Jan 1 2001, In : Endocrinology. 142, 12, p. 5254-5260 7 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Distinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakening

Seol, J., Fujii, Y., Park, I., Suzuki, Y., Kawana, F., Yajima, K., Fukusumi, S., Okura, T., Satoh, M., Tokuyama, K., Kokubo, T. & Yanagisawa, M., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24353-24358 6 p.

Research output: Contribution to journalArticle

Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: Molecular genetic dissection of non-REM and REM sleep regulatory processes

Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., Marcus, J. N., Lee, C., Elmquist, J. K., Kohlmeier, K. A., Leonard, C. S., Richardson, J. A., Hammer, R. E. & Yanagisawa, M., Jun 5 2003, In : Neuron. 38, 5, p. 715-730 16 p.

Research output: Contribution to journalArticle

464 Scopus citations

Distinct subdomains of human endothelin receptors determine their selectivity to endothelin(A)-selective antagonist and endothelin(B)-selective agonists

Sakamoto, A., Yanagisawa, M., Sawamura, T., Enoki, T., Ohtani, T., Sakurai, T., Nakao, K., Toyo-oka, T. & Masaki, T., Jan 1 1993, In : Journal of Biological Chemistry. 268, 12, p. 8547-8553 7 p.

Research output: Contribution to journalArticle

163 Scopus citations

Distinct vascular and intestinal smooth muscle myosin heavy chain mRNAs are encoded by a single-copy gene in the chicken

Hamada, Y., Yanagisawa, M., Katsuragawa, Y., Coleman, J. R., Nagata, S., Matsuda, G. & Masaki, T., Jul 16 1990, In : Biochemical and Biophysical Research Communications. 170, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain

Kitamura, Y., Tanaka, H., Motoike, T., Ishii, M., Williams, S. C., Yanagisawa, M. & Sakurai, T., Jun 6 2006, In : Brain Research. 1093, 1, p. 123-134 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Distribution of orexin neurons in the adult rat brain

Nambu, T., Sakurai, T., Mizukami, K., Hosoya, Y., Yanagisawa, M. & Goto, K., May 8 1999, In : Brain Research. 827, 1-2, p. 243-260 18 p.

Research output: Contribution to journalArticle

862 Scopus citations

Dlx5/6-Enhancer Directed Expression of Cre Recombinase in the Pharyngeal Arches and Brain

Ruest, L. B., Hammer, R. E., Yanagisawa, M. & Clouthier, D. E., Dec 1 2003, In : Genesis. 37, 4, p. 188-194 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

Yanagisawa, H., Yanagisawa, M., Kapur, R. P., Richardson, J. A., Williams, S. C., Clouthier, D. E., De Wit, D., Emoto, N. & Hammer, R. E., Apr 11 1998, In : Development. 125, 5, p. 825-836 12 p.

Research output: Contribution to journalArticle

408 Scopus citations

Dysregulation of Protease and Protease Inhibitors in a Mouse Model of Human Pelvic Organ Prolapse

Budatha, M., Silva, S., Montoya, T. I., Suzuki, A., Shah-Simpson, S., Wieslander, C. K., Yanagisawa, M., Word, R. A. & Yanagisawa, H., Feb 20 2013, In : PloS one. 8, 2, e56376.

Research output: Contribution to journalArticle

15 Scopus citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D. & Yanagisawa, M., Aug 12 1994, In : Cell. 78, 3, p. 473-485 13 p.

Research output: Contribution to journalArticle

835 Scopus citations

Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis

Morishima, M., Yanagisawa, H., Yanagisawa, M. & Baldini, A., Sep 1 2003, In : Developmental Dynamics. 228, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice

Willie, J. T., Takahira, H., Shibahara, M., Hara, J., Nomiyama, M., Yanagisawa, M. & Sakurai, T., Feb 1 2011, In : Journal of Molecular Neuroscience. 43, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Effect of endothelin on cardiovascular system

Masaki, T., Yanagisawa, M., Kimura, S., Takuwa, Y. & Goto, K., Jan 1 1990, In : Japanese Heart Journal. 31, 4, p. 517-518 2 p.

Research output: Contribution to journalArticle

Effect of endothelin receptor antagonist, BQ-123, on Ca2+ signaling in cultured rat mesangial cells

Yokokawa, K., Kohno, M., Johchi, M., Horio, T., Murakawa, K. I., Yasunari, K., Yanagisawa, M. & Takeda, T., 1993, In : Life Sciences. 53, 21, p. 1631-1641 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities

Aikawa, S., Ishii, M., Yanagisawa, M., Sakakibara, Y. & Sakurai, T., Nov 29 2008, In : Regulatory Peptides. 151, 1-3, p. 147-152 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice

Yasugaki, S., Liu, C. Y., Kashiwagi, M., Kanuka, M., Honda, T., Miyata, S., Yanagisawa, M. & Hayashi, Y., Oct 14 2019, In : Frontiers in Neuroscience. 13, 1072.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Effects of endothelin on the renal artery from spontaneously hypertensive and Wistar Kyoto rats

Tomobe, Y., Miyauchi, T., Saito, A., Yanagisawa, M., Kimura, S., Goto, K. & Masaki, T., Aug 2 1988, In : European Journal of Pharmacology. 152, 3, p. 373-374 2 p.

Research output: Contribution to journalArticle

196 Scopus citations

Effects of orexin (hypocretin) on GIRK channels

Hoang, Q. V., Bajic, D., Yanagisawa, M., Nakajima, S. & Nakajima, Y., Aug 1 2003, In : Journal of neurophysiology. 90, 2, p. 693-702 10 p.

Research output: Contribution to journalArticle

71 Scopus citations

Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice

Saitoh, A., Tominaga, H., Ogawa, Y., Irukayama-Tomobe, Y., Yamada, M., Yanagisawa, M. & Nagase, H., Apr 1 2018, In : Pharmacological Reports. 70, 2, p. 350-354 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M. & Gordon, J. I., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16767-16772 6 p.

Research output: Contribution to journalArticle

808 Scopus citations

Efficacy of administering an endothelin-receptor antagonist (SB209670) in ameliorating ischemia-reperfusion injury in lung allografts

Shennib, H., Lee, A. G. L., Kuang, J. Q., Yanagisawa, M., Ohlstein, E. H. & Giaid, A., Jan 1 1998, In : American journal of respiratory and critical care medicine. 157, 6 PART I, p. 1975-1981 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Elevated Expression of Endothelin-1 and Endothelin-converting Enzyme-1 in Idiopathic Pulmonary Fibrosis: Possible Involvement of Proinflammatory Cytokines

Saleh, D., Furukawa, K., Tsao, M. S., Maghazachi, A., Corrin, B., Yanagisawa, M., Barnes, P. J. & Giaid, A., Jan 1 1997, In : American journal of respiratory cell and molecular biology. 16, 2, p. 187-193 7 p.

Research output: Contribution to journalArticle

141 Scopus citations

Elevated plasma levels of endothelin‐1 in systemic sclerosis

Yamane, K., Kashiwagi, H., Suzuki, N., Miyauchi, T., Yanagisawa, M., Goto, K. & Masaki, T., Feb 1991, In : Arthritis & Rheumatism. 34, 2, p. 243-244 2 p.

Research output: Contribution to journalArticle

68 Scopus citations

Elevated systemic levels of endothelin-1 and blood pressure correlate with blunted constrictor responses and downregulation of endothelinA, but not endothelinB, receptors in an animal model of hypertension

Télémaque-Potts, S., Kuc, R. E., Maguire, J. J., Ohlstein, E., Yanagisawa, M. & Davenport, A. P., Aug 1 2002, In : Clinical science. 103, SUPPL. 48, p. 357S-362S

Research output: Contribution to journalArticle

14 Scopus citations

Elevation of blood pressure by genetic and pharmacological disruption of the ET(B) receptor in mice

Ohuchi, T., Kuwaki, T., Ling, G. Y., Dewit, D., Ju, K. H., Onodera, M., Cao, W. H., Yanagisawa, M. & Kumada, M., Apr 1 1999, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 276, 4 45-4, p. R1071-R1077

Research output: Contribution to journalArticle

94 Scopus citations

Elimination of intravenously injected endothelin-1 from the circulation of the rat

Shiba, R., Yanagisawa, M., Miyauchi, T., Ishii, Y., Kimura, S., Uchiyama, Y., Masaki, T. & Goto, K., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S98-S101

Research output: Contribution to journalArticle

104 Scopus citations

Emergence of clinical applications of endothelin system inhibitors

Goto, K., Miyauchi, T. & Yanagisawa, M., Nov 1 2004, In : Journal of Cardiovascular Pharmacology. 44, SUPPL. 1, p. xiii-xiv

Research output: Contribution to journalArticle

Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition

Widyantoro, B., Emoto, N., Nakayama, K., Anggrahini, D. W., Adiarto, S., Iwasa, N., Yagi, K., Miyagawa, K., Rikitake, Y., Suzuki, T., Kisanuki, Y. Y., Yanagisawa, M. & Hirata, K. I., Jun 8 2010, In : Circulation. 121, 22, p. 2407-2418 12 p.

Research output: Contribution to journalArticle

234 Scopus citations

Endothelial ETB limits vascular remodelling and development of pulmonary hypertension during hypoxia

Kelland, N. F., Bagnall, A. J., Morecroft, I., Gulliver-Sloan, F. H., Dempsie, Y., Nilsen, M., Yanagisawa, M., MacLean, M. R., Kotelevtsev, Y. V. & Webb, D. J., Jan 1 2009, In : Journal of Vascular Research. 47, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endothelin: New discoveries and rapid progress in the clinic

Webb, D. J., Monge, J. C., Rabelink, T. J. & Yanagisawa, M., Jan 1 1998, In : Trends in Pharmacological Sciences. 19, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

131 Scopus citations

Endothelin: A novel peptide in the posterior pituitary system

Yoshizawa, T., Shinmi, O., Giaid, A., Yanagisawa, M., Gibson, S. J., Kimura, S., Uchiyama, Y., Polak, J. M., Masaki, T. & Kanazawa, I., Jan 1 1990, In : Science. 247, 4941, p. 462-464 3 p.

Research output: Contribution to journalArticle

291 Scopus citations
355 Scopus citations

Endothelin, a novel vasoconstrictor peptide, as potent brochoconstrictor

Uchida, Y., Ninomiya, H., Saotome, M., Nomura, A., Ohtsuka, M., Yanagisawa, M., Goto, K., Masaki, T. & Hasegawa, S., Sep 13 1988, In : European Journal of Pharmacology. 154, 2, p. 227-228 2 p.

Research output: Contribution to journalArticle

260 Scopus citations

Endothelin, its diverse biological activities and mechanisms of action

Takuwa, Y., Yanagisawa, M., Takuwa, N. & Masaki, T., 1989, In : Progress in Growth Factor Research. 1, 4, p. 195-206 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia

Giaid, A., Gibson, S. J., Ibrahim, N. B. N., Legon, S., Bloom, S. R., Yanagisawa, M., Masaki, T., Varndell, I. M. & Polak, J. M., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 19, p. 7634-7638 5 p.

Research output: Contribution to journalArticle

Open Access
330 Scopus citations

Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis

Laghmani, K., Preisig, P. A., Moe, O. W., Yanagisawa, M. & Alpern, R. J., Jan 1 2001, In : Journal of Clinical Investigation. 107, 12, p. 1563-1569 7 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Endothelin-1 acts in cerebral arteries from the adventitial but not from the luminal side

Shigeno, T., Mima, T., Takakura, K., Yanagisawa, M., Saito, A., Goto, K. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S174-S176

Research output: Contribution to journalArticle

53 Scopus citations

Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat

Yoshimura, A., Iwasaki, S., Inui, K., Ideura, T., Koshikawa, S., Yanagisawa, M. & Masaki, T., Oct 1995, In : Kidney international. 48, 4, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Endothelin‐1 and Its Receptors in Human Testis

Maggi, M., Barni, T., Orlando, C., Fantoni, G., Finetti, G., Vannelli, G. B., Mancina, R., Gloria, L., Bonaccorsi, L., Yanagisawa, M. & Forti, G., Jan 1 1995, In : Journal of Andrology. 16, 3, p. 213-224 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Endothelin-1 as a master regulator of whole-body Na+ homeostasis

Speed, J. S., Heimlich, J. B., Hyndman, K. A., Fox, B. M., Patel, V., Yanagisawa, M., Pollock, J. S., Titze, J. M. & Pollock, D. M., Dec 1 2015, In : FASEB Journal. 29, 12, p. 4937-4944 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Endothelin-1 depolarizes a ventral root potential in the newborn rat spinal cord

Yoshizawa, T., Kimura, S., Kanazawa, I., Yanagisawa, M. & Masaki, T., Jan 1 1989, In : Journal of Cardiovascular Pharmacology. 13, p. S216-S217

Research output: Contribution to journalArticle

26 Scopus citations