• 71926 Citations
  • 119 h-Index
1984 …2020

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Article
1999

Endothelin A receptor is necessary for O2 constriction but not closure of ductus arteriosus

Coceani, F., Liu, Y. A., Seidlitz, E., Kelsey, L., Kuwaki, T., Ackerley, C. & Yanagisawa, M., Oct 1999, In : American Journal of Physiology - Heart and Circulatory Physiology. 277, 4 46-4, p. H1521-H1531

Research output: Contribution to journalArticle

55 Scopus citations

Endothelin in the central control of cardiovascular and respiratory functions

Kuwaki, T., Ling, G. Y., Onodera, M., Ishii, T., Nakamura, A., Ju, K. H., Cao, W. H., Kumada, M., Kurihara, H., Kurihara, Y., Yazaki, Y., Ohuchi, T., Yanagisawa, M. & Fukuda, Y., Dec 1 1999, In : Clinical and Experimental Pharmacology and Physiology. 26, 12, p. 989-994 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

ET(B) receptor activation leads to activation and phosphorylation of NHE3

Peng, Y., Moe, O. W., Chu, T. S., Preisig, P. A., Yanagisawa, M. & Alpern, R. J., Jan 1 1999, In : American Journal of Physiology - Cell Physiology. 276, 4 45-4, p. C938-C945

Research output: Contribution to journalArticle

36 Scopus citations

Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus

Håkansson, M. L., De Lecea, L., Sutcliffe, J. G., Yanagisawa, M. & Meister, B., Jul 29 1999, In : Journal of Neuroendocrinology. 11, 8, p. 653-663 11 p.

Research output: Contribution to journalArticle

204 Scopus citations

Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Clay Williams, S., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M., Aug 20 1999, In : Cell. 98, 4, p. 437-451 15 p.

Research output: Contribution to journalArticle

2353 Scopus citations

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

Moriguchi, T., Sakurai, T., Nambu, T., Yanagisawa, M. & Goto, K., Apr 2 1999, In : Neuroscience Letters. 264, 1-3, p. 101-104 4 p.

Research output: Contribution to journalArticle

237 Scopus citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M. & Nakazato, M., Jan 19 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 2, p. 748-753 6 p.

Research output: Contribution to journalArticle

879 Scopus citations

Structure and function of human prepro-orexin gene

Sakurai, T., Moriguchi, T., Furuya, K., Kajiwara, N., Nakamura, T., Yanagisawa, M. & Goto, K., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17771-17776 6 p.

Research output: Contribution to journalArticle

162 Scopus citations

Widespread distribution of orexin in rat brain and its regulation upon fasting

Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Yanagisawa, M. & Matsukura, S., Mar 24 1999, In : Biochemical and Biophysical Research Communications. 256, 3, p. 495-499 5 p.

Research output: Contribution to journalArticle

128 Scopus citations
1998

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

Elias, C. F., Saper, C. B., Maratos-Flier, E., Tritos, N. A., Lee, C., Kelly, J., Tatro, J. B., Huffman, G. E., Ollmann, M. M., Barsh, G. S., Sakurai, T., Yanagisawa, M. & Elmquist, J. K., Dec 28 1998, In : Journal of Comparative Neurology. 402, 4, p. 442-459 18 p.

Research output: Contribution to journalArticle

723 Scopus citations

Cloning and characterization of a novel endothelin receptor subtype in the avian class

Lecoin, L., Sakurai, T., Ngo, M. T., Abe, Y., Yanagisawa, M. & Le Douarin, N. M., Mar 17 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 6, p. 3024-3029 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

Yanagisawa, H., Yanagisawa, M., Kapur, R. P., Richardson, J. A., Williams, S. C., Clouthier, D. E., De Wit, D., Emoto, N. & Hammer, R. E., Apr 11 1998, In : Development. 125, 5, p. 825-836 12 p.

Research output: Contribution to journalArticle

408 Scopus citations

Efficacy of administering an endothelin-receptor antagonist (SB209670) in ameliorating ischemia-reperfusion injury in lung allografts

Shennib, H., Lee, A. G. L., Kuang, J. Q., Yanagisawa, M., Ohlstein, E. H. & Giaid, A., Jan 1 1998, In : American journal of respiratory and critical care medicine. 157, 6 PART I, p. 1975-1981 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endothelin: New discoveries and rapid progress in the clinic

Webb, D. J., Monge, J. C., Rabelink, T. J. & Yanagisawa, M., Jan 1 1998, In : Trends in Pharmacological Sciences. 19, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

131 Scopus citations

Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells

Takizawa, H., Desaki, M., Ohtoshi, T., Kawasaki, S., Kohyama, T., Sato, M., Nakajima, J., Yanagisawa, M. & Ito, K., Jul 1 1998, In : European Respiratory Journal. 12, 1, p. 57-63 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats

Télémaque, S., Emoto, N., DeWit, D. & Yanagisawa, M., Jan 1 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S548-S550

Research output: Contribution to journalArticle

18 Scopus citations

Novel mutations of the endothelin B receptor gene in patients with Hirschsprung's disease and their characterization

Tanaka, H., Moroi, K., Iwai, J., Takahashi, H., Ohnuma, N., Hori, S., Takimoto, M., Nishiyama, M., Masaki, T., Yanagisawa, M., Sekiya, S. & Kimura, S., May 1 1998, In : Journal of Biological Chemistry. 273, 18, p. 11378-11383 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Novel selective quinazoline inhibitors of endothelin converting enzyme-1

Ahn, K., Sisneros, A. M., Herman, S. B., Pan, S. M., Hupe, D., Lee, C., Nikam, S., Cheng, X. M., Doherty, A. M., Schroeder, R. L., Haleen, S. J., Kaw, S., Emoto, N. & Yanagisawa, M., Feb 4 1998, In : Biochemical and Biophysical Research Communications. 243, 1, p. 184-190 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W. S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & 1 others, Yanagisawa, M., Feb 20 1998, In : Cell. 92, 4, p. 573-585 13 p.

Research output: Contribution to journalArticle

2611 Scopus citations

Pharmacology of endothelins in vascular circuits of normal or heterozygous endothelin-A or endothelin-B knockout transgenic mice

Berthiaume, N., Yanagisawa, M., Yanagisawa, H., DeWit, D. & D'Orléans-Juste, P., Jan 1 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S561-S564

Research output: Contribution to journalArticle

14 Scopus citations

Pulmonary disease models induced by in vivo hemagglutinating virus of Japan liposome-mediated endothelin-1 gene transfer

Takeda, S. I., Miyoshi, S., Omori, K. I., Utsumi, T., Kogaki, S., Sawa, Y., Yanagisawa, M. & Matsuda, H., Jan 1 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S336-S338

Research output: Contribution to journalArticle

4 Scopus citations

Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Williams, S. C., Clouthier, D. E. & Yanagisawa, M., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

Open Access
164 Scopus citations

The expression pattern of endothelin 3 in the avian embryo

Nataf, V., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., May 1 1998, In : Mechanisms of Development. 73, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo

Nataf, V., Grapin-Botton, A., Champeval, D., Amemiya, A., Yanagisawa, M. & Le Douarin, N. M., Jul 1998, In : Mechanisms of Development. 75, 1-2, p. 145-149 5 p.

Research output: Contribution to journalArticle

30 Scopus citations
Open Access
145 Scopus citations
1997

Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse

Mizuguchi, T., Nishiyama, M., Moroi, K., Tanaka, H., Saito, T., Masuda, Y., Masaki, T., De Wit, D., Yanagisawa, M. & Kimura, S., Jan 1 1997, In : British Journal of Pharmacology. 120, 8, p. 1427-1430 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

Elevated Expression of Endothelin-1 and Endothelin-converting Enzyme-1 in Idiopathic Pulmonary Fibrosis: Possible Involvement of Proinflammatory Cytokines

Saleh, D., Furukawa, K., Tsao, M. S., Maghazachi, A., Corrin, B., Yanagisawa, M., Barnes, P. J. & Giaid, A., Jan 1 1997, In : American journal of respiratory cell and molecular biology. 16, 2, p. 187-193 7 p.

Research output: Contribution to journalArticle

141 Scopus citations

Endothelin and its signaling - Genetic analysis in mice

Yanagisawa, M., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1450

Research output: Contribution to journalArticle

Experimental bronchiolitis obliterans induced by in vivo HVJ-liposome- mediated endothelin-1 gene transfer

Takeda, S. I., Sawa, Y., Minami, M., Kaneda, Y., Fujii, Y., Shirakura, R., Yanagisawa, M. & Matsuda, H., Jun 1997, In : Annals of Thoracic Surgery. 63, 6, p. 1562-1567 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Gene therapy for Hirschsprung disease?

Kapur, R. P., Yanagisawa, M., Yanagisawa, H. & Rice, J., Dec 1 1997, In : Pediatric Pathology and Laboratory Medicine. 17, 3, p. 516-517 2 p.

Research output: Contribution to journalArticle

Localization of endothelin-converting enzyme-1 in human kidney

Pupilli, C., Romagnani, P., Lasagni, L., Bellini, F., Misciglia, N., Emoto, N., Yanagisawa, M., Rizzo, M., Mannelli, M. & Serio, M., Dec 9 1997, In : American Journal of Physiology - Renal Physiology. 273, 5 42-5, p. F749-F756

Research output: Contribution to journalArticle

27 Scopus citations

Studies on endothelium-dependent vasorelaxation by hydralazine in porcine coronary artery

Wei, S., Kasuya, Y., Yanagisawa, M., Kimura, S., Masaki, T. & Goto, K., Mar 5 1997, In : European Journal of Pharmacology. 321, 3, p. 307-314 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
1996

Co-expression of Endothelin-1 and Endothelin-Converting Enzyme-1 in Patients with Chronic Rhinitis

Furukawa, K., Saleh, D., Bayan, F., Emoto, N., Kaw, S., Yanagisawa, M. & Giaid, A., Jan 1 1996, In : American journal of respiratory cell and molecular biology. 14, 3, p. 248-253 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

EndothelinB receptor activates NHE-3 by a Ca2+ -dependent pathway in OKP cells

Chu, T. S., Peng, Y., Cano, A., Yanagisawa, M. & Alpern, R. J., Mar 15 1996, In : Journal of Clinical Investigation. 97, 6, p. 1454-1462 9 p.

Research output: Contribution to journalArticle

Open Access
65 Scopus citations

Expression of endothelin-1 in pancreatic tissue of patients with chronic pancreatitis

Kakugawa, Y., Giaid, A., Yanagisawa, M., Baynash, A. G., Melnyk, P., Rosenberg, L. & Duguid, W. P., Feb 9 1996, In : Journal of Pathology. 178, 1, p. 78-83 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Novel quinazoline endothelin converting enzyme inhibitors

Ahn, K., Sisneros, A. M., Pan, S., Hupe, D., Kam, S. N., Lee, C., Doherty, A., Kaw, S., Emoto, N. & Yanagisawa, M., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1404

Research output: Contribution to journalArticle

1 Scopus citations
172 Scopus citations

Rediscovering an endothelin antagonist (BQ-123): A self-deconvoluting cyclic pentapeptide library

Spatola, A. F., Crozet, Y., DeWit, D. & Yanagisawa, M., Sep 13 1996, In : Journal of Medicinal Chemistry. 39, 19, p. 3842-3846 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

Role of tyrosine kinase pathways in ET(B) receptor activation of NHE3

Chu, T. S., Tsuganezawa, H., Peng, Y., Cano, A., Yanagisawa, M. & Alpern, R. J., Sep 1 1996, In : American Journal of Physiology - Cell Physiology. 271, 3 40-3, p. C763-C771

Research output: Contribution to journalArticle

36 Scopus citations

Systemic hypertension induced by hepatic overexpression of human preproendothelin-1 in rats

Niranjan, V., Télémaque, S., De Wit, D., Gerard, R. D. & Yanagisawa, M., Nov 15 1996, In : Journal of Clinical Investigation. 98, 10, p. 2364-2372 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
1995

Analysis of C5a receptor by monoclonal antibody

Watanabe, H., Kuraya, M., Kasukawa, R., Yanagisawa, H., Yanagisawa, M. & Fujita, T., Sep 11 1995, In : Journal of Immunological Methods. 185, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat

Yoshimura, A., Iwasaki, S., Inui, K., Ideura, T., Koshikawa, S., Yanagisawa, M. & Masaki, T., Oct 1995, In : Kidney international. 48, 4, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Endothelin‐1 and Its Receptors in Human Testis

Maggi, M., Barni, T., Orlando, C., Fantoni, G., Finetti, G., Vannelli, G. B., Mancina, R., Gloria, L., Bonaccorsi, L., Yanagisawa, M. & Forti, G., Jan 1 1995, In : Journal of Andrology. 16, 3, p. 213-224 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Endothelin-1 immunoreactivity and mRNA in the transplanted human heart

Giaid, A., Saleh, D., Yanagisawa, M. & Forbes, R. D. C., May 15 1995, In : Transplantation. 59, 9, p. 1308-1313 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum

Emoto, N. & Yanagisawa, M., Jun 23 1995, In : Journal of Biological Chemistry. 270, 25, p. 15262-15268 7 p.

Research output: Contribution to journalArticle

Open Access
424 Scopus citations

Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia

Tonnessen, T., Giaid, A., Saleh, D., Naess, P. A., Yanagisawa, M. & Christensen, G., May 1995, In : Circulation research. 76, 5, p. 767-772 6 p.

Research output: Contribution to journalArticle

120 Scopus citations
1994

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

Puffenberger, E. G., Hosoda, K., Washington, S. S., Nakao, K., deWit, D., Yanagisawa, M. & Chakravarti, A., Dec 30 1994, In : Cell. 79, 7, p. 1257-1266 10 p.

Research output: Contribution to journalArticle

732 Scopus citations

Autoregulation of endothelin-1 secretion by cultured human keratinocytes via the endothelin B receptor

Yohn, J. J., Smith, C., Stevens, T., Morelli, J. G., Shurnas, L. R., Walchak, S. J., Hoffman, T. A., Kelley, K. K., Escobedo-Morse, A., Yanagisawa, M., Kane, M. A. & Zamora, M. R., Dec 30 1994, In : BBA - Molecular Cell Research. 1224, 3, p. 454-458 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D. & Yanagisawa, M., Aug 12 1994, In : Cell. 78, 3, p. 473-485 13 p.

Research output: Contribution to journalArticle

835 Scopus citations